Spi-B Antibody

Novus Biologicals | Catalog # NBP1-70345

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Bovine, Canine, Equine, Primate

Predicted:

Chimpanzee (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all Spi-B Primary Antibodies »

Product Specifications

Immunogen

A portion of amino acid 15-65 of human Spi-B was used as the immunogen.

Reactivity Notes

Predicted to react in Lizard. Immunogen displays the following percentage of sequence identity for non-tested species: Rat (82%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Spi-B Antibody

Western Blot: Spi-B Antibody [NBP1-70345]

Western Blot: Spi-B Antibody [NBP1-70345]

Western Blot: SPIB Antibody [NBP1-70345] - Analysis of Spi-B in human Daudi lysate in the 1) absence and 2) presence of immunizing peptide and 3) on mouse RAW lysate using Spi-B polyclonal antibody at 4 ug/ml.

Applications for Spi-B Antibody

Application
Recommended Usage

Western Blot

3-5 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS containing 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Spi-B

Transcription factor Spi-B belongs to the ETS family and contains one ETS DNA-binding domain. Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression, thus maintains activity of germinal center and memory B cells by direct repression of major plasma cell factors and thereby plasma cell differentiation. It is reported that Spi-B regulates Progressive multifocal leukoencephalopathy (PML) causing JCVirus gene expression, and may play an important role in JCV activity in the immune and nervous systems. It is also reported Spi-B is expressed in various murine and hematopoietic lines except T lymphoid lines.

Long Name

Transcription Factor Spi [Spleen FFV Proviral Integration Oncogene] B

Alternate Names

SpiB

Gene Symbol

SPIB

UniProt

Q01892 (Human)

Additional Spi-B Products

Product Documents for Spi-B Antibody

Certificate of Analysis

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Product Specific Notices for Spi-B Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

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Associated Pathways

Dendritic Cell Lineage Development Pathways Dendritic Cell Lineage Development Pathway Thumbnail