Chemical Name: (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
Biological ActivityCompetitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology.
Delyani et al.
Kidney Int., 2000;57:1408
A comparison of the aldosterone-blocking agents eplernone and spironola.
Struthers et al.
Contrasting effects of epler. and spironola. on adrenal cell steroidogenesis.
Ye et al.
Citations for Spironolactone
The citations listed below are publications that use Tocris products. Selected citations for Spironolactone include:
3 Citations: Showing 1 - 3
Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin.
Authors: Pinheiro Et al.
Brain Res Bull 2016;124:222
Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents.
Authors: Liu Et al.
Mol Brain 2014;7:32
Effects of acute restraint stress on set-shifting and reversal learning in male rats.
Authors: Thai Et al.
Cogn Affect Behav Neurosci 2013;13:164
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