Catalog Number: 2968
Alternate Names: SC 9420, Aldactone
Chemical Name: (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
Biological Activity
Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology.
    Delyani et al.
    Kidney Int., 2000;57:1408
  2. A comparison of the aldosterone-blocking agents eplernone and spironolactone.
    Struthers et al.
    Clin.Cardiol., 2008;31:153
  3. Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis.
    Ye et al.
    Horm.Metab.Res., 2009;41:35

The citations listed below are publications that use Tocris products. Selected citations for Spironolactone include:

Showing Results 1 - 1 of 1

  1. Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents.
    Authors: Liu Et al.
    Mol Brain
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information