Catalog Number: 2968
Alternate Names: SC 9420, Aldactone
Chemical Name: (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
Biological Activity
Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.
Technical Data
  • M.Wt:
    416.57
  • Formula:
    C24H32O4S
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    52-01-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology.
    Delyani et al.
    Kidney Int., 2000;57:1408
  2. A comparison of the aldosterone-blocking agents eplernone and spironolactone.
    Struthers et al.
    Clin.Cardiol., 2008;31:153
  3. Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis.
    Ye et al.
    Horm.Metab.Res., 2009;41:35
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Spironolactone include:

1 Citations: Showing 1 - 1

  1. Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents.
    Authors: Liu Et al.
    Mol Brain 2014;7:32

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