Catalog Number: 2309
Chemical Name: 2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid
Biological Activity
Potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.
Technical Data
  • M.Wt:
    685.86
  • Formula:
    C39H51N5O6
  • Solubility:
    Soluble to 75 mM in DMSO and to 25 mM in water
  • Purity:
    >97%
  • Storage:
    Store at +4°C
  • CAS No:
    184162-64-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist.
    Gully et al.
    J.Pharmacol.Exp.Ther., 1997;280:802
  2. X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist.
    Quere et al.
    Bioorg.Med.Chem.Lett., 1998;8:653
  3. Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice.
    Marie-Claire et al.
    Neuropharmacology, 2008;54:1107
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SR 142948 include:

3 Citations: Showing 1 - 3
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  1. Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyr[11]neurotensin.
    Authors: Rouibi Et al.
    J Cereb Blood Flow Metab 2016;9:470
  2. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons.
    Authors: Piccart Et al.
    J Neurosci 2015;35:11144
  3. Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.
    Authors: Yin Et al.
    Neuropharmacology 2008;54:79

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