SR 142948

  ( 4 citations )    
Product Datasheet
Catalog Number:2309
Chemical Name:2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.
Technical Data
  • M.Wt:
    685.86
  • Formula:
    C39H51N5O6
  • Solubility:
    Soluble to 75 mM in DMSO and to 25 mM in water
  • Purity:
    >97
  • Storage:
    Store at +4°C
  • CAS No:
    184162-64-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SR 142948 include:

4 Citations: Showing 1 - 4
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  1. Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyr[11]neurotensin.
    Authors: Rouibi Et al.
    J Cereb Blood Flow Metab  2016;9:470
  2. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons.
    Authors: Piccart Et al.
    J Neurosci  2015;35:11144
  3. Dependence of Relative Expression of NTR1 and EGFR on Cell Density and Extracellular pH in Human Pancreatic Cancer Cell Lines.
    Authors: Olszewski-Hamilton and Hamilton
    Cancers (Basel)  2011;3:182
  4. Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.
    Authors: Yin Et al.
    Neuropharmacology  2008;54:79

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