SR 142948

Tocris Bioscience | Catalog # 2309

Highly potent NTS receptor antagonist
Tocris Bioscience

Key Product Details

Description

Highly potent NTS receptor antagonist
View all Neurotensin Receptor Antagonists »

Product Description

SR 142948 is a potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.

Product Specifications for SR 142948

Molecular Weight

685.86

Formula

C39H51N5O6

Storage

Store at +4°C

Purity

≥97% (HPLC)

Chemical Name

2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid

CAS Number

184162-64-9

PubChem ID

5311451

InChI Key

LWULHXVBLMWCHO-UHFFFAOYSA-N

SMILES

COC1=CC=CC(OC)=C1C1=CC(=NN1C1=C(C=C(C=C1)C(=O)N(C)CCCN(C)C)C(C)C)C(=O)NC1(C2CC3CC(C2)CC1C3)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.15 25
DMSO 51.44 75

Preparing Stock Solutions for SR 142948

The following data is based on the product molecular weight 685.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 1.94 mL 9.72 mL 19.44 mL
3.75 mM 0.39 mL 1.94 mL 3.89 mL
7.5 mM 0.19 mL 0.97 mL 1.94 mL
37.5 mM 0.04 mL 0.19 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

Product Documents for SR 142948

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SR 142948

For research use only

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