SSR 146977 hydrochloride

Tocris Bioscience | Catalog # 3297

Potent and selective NK3 antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective NK3 antagonist
View all NK3 Receptor Antagonists »

Product Description

SSR 146977 hydrochloride is a potent and selective NK3 receptor antagonist (Ki values are 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor respectively). Also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM).

Product Specifications for SSR 146977 hydrochloride

Molecular Weight

658.11

Formula

C35H42Cl2N4O2.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N1-[1-3-[(3R)-1-Benzoyl-3-(3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-piperidinyl]-N,N-dimethylurea hydrochloride

CAS Number

264618-38-4

PubChem ID

90488827

InChI Key

HYPKKQPFHSNZBY-GXUZKUJRSA-N

SMILES

O=C(N(C)C)NC1(C4=CC=CC=C4)CCN(CCC[C@]3(CN(C(C5=CC=CC=C5)=O)CCC3)[C@]2=CC=C(Cl)C(Cl)=C2)CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 65.81 100
Ethanol 65.81 100

Preparing Stock Solutions for SSR 146977 hydrochloride

The following data is based on the product molecular weight 658.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.52 mL 7.60 mL 15.20 mL
5 mM 0.30 mL 1.52 mL 3.04 mL
10 mM 0.15 mL 0.76 mL 1.52 mL
50 mM 0.03 mL 0.15 mL 0.30 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for SSR 146977 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SSR 146977 hydrochloride

For research use only

Citations for SSR 146977 hydrochloride

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