Potent and selective NK3
receptor antagonist (Ki
values are 0.26 and 19.3 nM in CHO cells expressing the human NK3
receptor respectively). Also inhibits senktide
-induced inositol monophosphate formation and intracellular calcium mobilization (IC50
= 10 nM).
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All Tocris products are intended for laboratory research use only.
Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist.
Emonds-Alt et al.