Partial agonist at α
7 nAChR. Enhances episodic memory and reverses MK-801
-induced deficits in retention of episodic memory. Increases extracellular dopamine levels in rat prefrontal cortex. Also exhibits antidepressant-like properties.
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Effect of α7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats.
Jones et al.
Psychopharmacology (Berl)., 2014;231:673
SSR180711, a novel selective α7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.
Pichat et al.