Catalog Number: 5559
Chemical Name: 4-Bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate hydrochloride
Biological Activity
Partial agonist at α7 nAChR. Enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. Increases extracellular dopamine levels in rat prefrontal cortex. Also exhibits antidepressant-like properties.
Technical Data
  • M.Wt:
    361.66
  • Formula:
    C14H17BrN2O2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    446031-79-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effect of α7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats.
    Jones et al.
    Psychopharmacology (Berl)., 2014;231:673
  2. SSR180711, a novel selective α7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.
    Pichat et al.
    Neuropsychopharmacology, 2007;32:17

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