SSR 180711 hydrochloride
Chemical Name: 4-Bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate hydrochloride
Biological ActivityPartial agonist at α7 nAChR. Enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. Increases extracellular dopamine levels in rat prefrontal cortex. Also exhibits antidepressant-like properties.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Effect of α7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats.
Jones et al.
Psychopharmacology (Berl)., 2014;231:673
SSR180711, a novel selective α7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.
Pichat et al.
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