Sunitinib malate

Key Product Details

Product Description

Sunitinib malate is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (K_i values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Sunitinib malate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Sunitinib malate

The following data is based on the product molecular weight 532.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	7.51 mL	37.55 mL	75.11 mL
1.25 mM	1.50 mL	7.51 mL	15.02 mL
2.5 mM	0.75 mL	3.76 mL	7.51 mL
12.5 mM	0.15 mL	0.75 mL	1.50 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Roskoski Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem.Biophys.Res.Comm. 2007 PMID: 17367763
• O'Farrell SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 2003 PMID: 12531805
• Faivre Molecular basis for suni. efficacy and future clinical development Nat.Rev.Drug Discov. 2007 PMID: 17690708
• Mendel In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin.Cancer Res. 2003 PMID: 12538485

Product Documents for Sunitinib malate