Sunitinib malate

  ( 3 citations )    
Product Datasheet
Catalog Number:3768
Alternate Names:SU 11248
Chemical Name:N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioate salt
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.
Technical Data
  • M.Wt:
    532.56
  • Formula:
    C22H27FN4O2.C4H6O5
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    341031-54-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Sunitinib malate include:

3 Citations: Showing 1 - 3
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  1. Feedback circuitry between miR-218 repression and RTK activation in glioblastoma.
    Authors: Mathew Et al.
    Cell Death Differ  2015;8:ra42
  2. VEGF???-conjugated mesoporous silica nanoparticle: a tumor targeted drug delivery system.
    Authors: Goel Et al.
    ACS Appl Mater Interfaces  2014;6:21677
  3. Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility.
    Authors: Procaccia Et al.
    Biochem Biophys Res Commun  2014;448:134

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