Sunitinib malate

Catalog # Availability Size / Price Qty
3768/10
3768/50
Sunitinib malate | CAS No. 341031-54-7 | VEGF Receptor Inhibitors
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Description: Potent VEGFR, PDGFRβ and KIT inhibitor
Alternative Names: SU 11248

Chemical Name: N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioate salt

Purity: ≥99%

Product Details
Citations (4)
Supplemental Products
Reviews

Biological Activity

Potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.

Technical Data

M.Wt:
532.56
Formula:
C22H27FN4O2.C4H6O5
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
341031-54-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.
    Mendel et al.
    Clin.Cancer Res., 2003;9:327
  2. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo.
    O'Farrell et al.
    Blood, 2003;101:3597
  3. Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor.
    Roskoski
    Biochem.Biophys.Res.Comm., 2007;356:323
  4. Molecular basis for suni. efficacy and future clinical development
    Faivre et al.
    Nat.Rev.Drug Discov., 2007;6:734

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Citations for Sunitinib malate

The citations listed below are publications that use Tocris products. Selected citations for Sunitinib malate include:

4 Citations: Showing 1 - 4

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