SYPL2 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-77362

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Rabbit (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
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Product Specifications

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SYPL. The immunogen is located within the last 50 amino acids of SYPL2.

Specificity

At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SYPL2 Antibody - BSA Free

Western Blot: SYPL2 AntibodyBSA Free [NBP1-77362]

Western Blot: SYPL2 AntibodyBSA Free [NBP1-77362]

Western Blot: SYPL2 Antibody [NBP1-77362] - Human spleen tissue lysate with SYPL2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
SYPL2 Antibody - BSA Free

Immunohistochemistry: SYPL2 Antibody - BSA Free [NBP1-77362] -

Immunohistochemistry: SYPL2 Antibody - BSA Free [NBP1-77362] - Immunohistochemistry of SYPL2 in human spleen tissue with SYPL2 antibody at 2.5 ug/mL.
SYPL2 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: SYPL2 Antibody - BSA Free [NBP1-77362] -

Immunocytochemistry/ Immunofluorescence: SYPL2 Antibody - BSA Free [NBP1-77362] - Immunofluorescence of SYPL2 in Human Spleen cells with SYPL2 antibody at 20 ug/mL.

Applications for SYPL2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SYPL2

SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores. At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.

Alternate Names

MG29, mitsugumin-29, synaptophysin-like 2, synaptophysin-like protein 2

Gene Symbol

SYPL2

Additional SYPL2 Products

Product Documents for SYPL2 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for SYPL2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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