T 0070907

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2301/25
2301/5
T 0070907 | CAS No. 313516-66-4 | PPAR gamma Receptor Antagonists
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Description: Highly potent and selective covalent PPARγ antagonist

Chemical Name: 2-Chloro-5-nitro-N-4-pyridinylbenzamide

Purity: ≥99%

Product Details
Citations (4)
Supplemental Products
Reviews (1)

Biological Activity

Potent and selective irreversible PPARγ antagonist (IC50 = 1 nM). Displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. Blocks transcriptional activity of PPARγ in vitro and inhibits rosiglitazone-induced adipogenesis.

Technical Data

M.Wt:
277.67
Formula:
C12H8N3O3Cl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥99%
Storage:
Store at RT
CAS No:
313516-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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T 0070907 inhibits 15d-PGJ2-induced ERK activation in cardiomyocytes
By Chintan Koyani on 12/10/2018
Species: Mouse

HL-1 cardiomyocytes were incubated with T 0070907 (1 µM) for 30 min prior to addition of 15 µM 15d-PGJ2 for 30 min. Preincubation of cells with T 0070907 completely abolished activation of p42/44 MAPK indicating involvement of PPAR gamma in cellular signalling in response to 15d-PGJ2.


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