Catalog Number: 2301
Chemical Name: 2-Chloro-5-nitro-N-4-pyridinylbenzamide
Biological Activity
Potent and selective irreversible PPARγ antagonist (IC50 = 1 nM). Displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. Blocks transcriptional activity of PPARγ in vitro and inhibits rosiglitazone-induced adipogenesis.
Technical Data
  • M.Wt:
    277.67
  • Formula:
    C12H8N3O3Cl
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    313516-66-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. T0070907, a selective ligand for peroxisome proliferator-activated receptor γ, functions as an antagonist of biochemical and cellular activities.
    Lee et al.
    J.Biol.Chem., 2002;277:19649
  2. A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes.
    Rockwell and Kaminski
    J.Pharmacol.Exp.Ther., 2004;311:683
  3. Peroxisome proliferator-activated receptor γ inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells.
    Schaefer et al.
    Cancer Res., 2005;65:2251
Citations:

The citations listed below are publications that use Tocris products. Selected citations for T 0070907 include:

1 Citations: Showing 1 - 1

  1. The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype.
    Authors: Bullers Et al.
    Tissue Eng Part A 2014;20:2390

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