Chemical Name: 2-Chloro-5-nitro-N-4-pyridinylbenzamide
Biological ActivityPotent and selective irreversible PPARγ antagonist (IC50 = 1 nM). Displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. Blocks transcriptional activity of PPARγ in vitro and inhibits rosiglitazone-induced adipogenesis.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
T0070907, a selective ligand for peroxisome proliferator-activated receptor γ, functions as an antagonist of biochemical and cellular activities.
Lee et al.
A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes.
Rockwell and Kaminski
Peroxisome proliferator-activated receptor γ inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells.
Schaefer et al.
Cancer Res., 2005;65:2251
Citations for T 0070907
The citations listed below are publications that use Tocris products. Selected citations for T 0070907 include:
4 Citations: Showing 1 - 4
Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling.
Authors: Kassotis Et al.
Sci Rep 2017;7:42104
The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype.
Authors: Bullers Et al.
Tissue Eng Part A 2014;20:2390
The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.
Authors: Hamtiaux Et al.
BMC Cancer 2012;12:92
Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.
Authors: Hamtiaux Et al.
PLoS One 2011;6:e26823
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HL-1 cardiomyocytes were incubated with T 0070907 (1 µM) for 30 min prior to addition of 15 µM 15d-PGJ2 for 30 min. Preincubation of cells with T 0070907 completely abolished activation of p42/44 MAPK indicating involvement of PPAR gamma in cellular signalling in response to 15d-PGJ2.