T 0070907

Tocris Bioscience | Catalog # 2301

Highly potent and selective covalent PPARγ antagonist
Tocris Bioscience

Key Product Details

Description

Highly potent and selective covalent PPARγ antagonist
View all PPAR gamma Receptor Antagonists »

Product Description

T 0070907 is a potent and selective irreversible PPARγ antagonist (IC50 = 1 nM). Displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. Blocks transcriptional activity of PPARγ in vitro and inhibits Rosiglitazone-induced adipogenesis.

Product Specifications for T 0070907

Molecular Weight

277.67

Formula

C12H8N3O3Cl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-Chloro-5-nitro-N-4-pyridinylbenzamide

CAS Number

313516-66-4

PubChem ID

2777391

InChI Key

FRPJSHKMZHWJBE-UHFFFAOYSA-N

SMILES

[O-][N+](=O)C1=CC=C(Cl)C(=C1)C(=O)NC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 27.77 100
DMSO 27.8 100

Preparing Stock Solutions for T 0070907

The following data is based on the product molecular weight 277.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.60 mL 18.01 mL 36.01 mL
5 mM 0.72 mL 3.60 mL 7.20 mL
10 mM 0.36 mL 1.80 mL 3.60 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 54 publications citing the usage of this product.

Product Documents for T 0070907

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for T 0070907

For research use only

Customer Reviews for T 0070907 (2)

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  • Great T 0070907
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: Eye
    Verified Customer | Posted 12/05/2021
    10 microM T 0070907 was used in the mouse and it blunt EC sprouting.
    T 0070907 2301
  • T 0070907 inhibits 15d-PGJ2-induced ERK activation in cardiomyocytes
    Name: Chintan Koyani
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: HL-1 cardiomyocytes
    Verified Customer | Posted 12/10/2018
    HL-1 cardiomyocytes were incubated with T 0070907 (1 µM) for 30 min prior to addition of 15 µM 15d-PGJ2 for 30 min. Preincubation of cells with T 0070907 completely abolished activation of p42/44 MAPK indicating involvement of PPAR gamma in cellular signalling in response to 15d-PGJ2.
    T 0070907 2301

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