Potent and selective PPARγ
= 60 nM); exhibits no activity at PPARα
. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Exhibits antihyperglycemic activity in diabetic ob/ob
mouse model. Antidiabetic agent.
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All Tocris products are intended for laboratory research use only.
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).
Lehmann et al.
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.
Willson et al.
The citations listed below are publications that use Tocris products. Selected citations for Rosiglitazone include:
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