Catalog # Availability Size / Price Qty
Rosiglitazone | CAS No. 122320-73-4 | PPAR gamma Receptor Agonists
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Description: Potent and selective PPARγ agonist; antidiabetic agent
Alternative Names: BRL 49653

Chemical Name: 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

Purity: ≥98%

Product Details
Citations (15)
Supplemental Products

Biological Activity

Rosiglitazone is a potent and selective PPARγ agonist (EC50 = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Also promotes differentiation of urothelial organoids in combination with Erlotinib (Cat. No. 7194). Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Rosiglitazone

The citations listed below are publications that use Tocris products. Selected citations for Rosiglitazone include:

15 Citations: Showing 1 - 10

  1. Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy.
    Authors: Elisabetta Et al.
    EMBO Mol Med  2023;15:e16225
  2. Ketogenic diet prevents paclitaxel-induced neuropathic nociception through activation of PPARγ signalling pathway and inhibition of neuroinflammation in rat dorsal root ganglion.
    Authors: Chang Et al.
    Eur J Neurosci  2021;54:5341-5356
  3. Three of a Kind: Control of the Expression of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) by the Endocannabinoidome and the Gut Microbiome.
    Authors: Vincenzo Et al.
    Molecules  2021;27
  4. Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists.
    Authors: Vincenzo Et al.
    Cells  2021;10
  5. Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State.
    Authors: Liang Et al.
    Cell Stem Cell  2020;27:784-797.e11
  6. Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa, as a Novel PPARγ Agonist via a Combined Computational and Functional Study.
    Authors: Luciano Et al.
    Molecules  2020;25
  7. Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets
    Authors: Fellous Et al.
    Biochemical Pharmacology  2020;175
  8. Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties.
    Authors: Smith Et al.
    Psychopharmacology (Berl)  2019;
  9. A structural mechanism for directing corepressor-selective inverse agonism of PPARγ.
    Authors: Brust Et al.
    Nat Commun  2018;9:4687
  10. Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest.
    Authors: Vitale Et al.
    Mar Drugs  2018;16


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