Rosiglitazone

Tocris Bioscience | Catalog # 5325

Potent and selective PPARγ agonist; antidiabetic agent
Tocris Bioscience

Key Product Details

Description

Potent and selective PPARγ agonist; antidiabetic agent

Alternative Names

BRL 49653
View all PPAR gamma Receptor Agonists »

Product Description

Rosiglitazone is a potent and selective PPARγ agonist (EC50 = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Also promotes differentiation of urothelial organoids in combination with Erlotinib (Cat. No. 7194). Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent.

Product Specifications for Rosiglitazone

Molecular Weight

357.43

Formula

C18H19N3O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

CAS Number

122320-73-4

PubChem ID

77999

InChI Key

YASAKCUCGLMORW-UHFFFAOYSA-N

SMILES

CN(CCOC1=CC=C(CC2SC(NC2=O)=O)C=C1)C3=CC=CC=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.74 100

Preparing Stock Solutions for Rosiglitazone

The following data is based on the product molecular weight 357.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.80 mL 13.99 mL 27.98 mL
5 mM 0.56 mL 2.80 mL 5.60 mL
10 mM 0.28 mL 1.40 mL 2.80 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 55 publications citing the usage of this product.

Product Documents for Rosiglitazone

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Rosiglitazone

For research use only

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  • Agonist dose-response analyses of the Human PPAR gamma Assay.
    Name: GAJANAN KATKAR
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: PPARg reporter cells
    Verified Customer | Posted 12/07/2019
    PPAR gamma Assay was performed using manual dispensing and following the protocol described in this Technical Manual, using the Rosiglitazone. PPAR gamma reporter cells treated with 2,500 nM Rosiglitazone yielded an average RLU value with CV=7%, S/B = 162 and a corresponding Z’= 0.78.

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