Rosiglitazone

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5325/10
5325/50
Rosiglitazone | CAS No. 122320-73-4 | PPAR gamma Receptor Agonists
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Description: Potent and selective PPARγ agonist; antidiabetic agent
Alternative Names: BRL 49653

Chemical Name: 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

Purity: ≥99%

Product Details
Citations (7)
Supplemental Products
Reviews (1)

Biological Activity

Potent and selective PPARγ agonist (EC50 = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Also promotes differentiation of urothelial organoids in combination with erlotinib. Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent.

Technical Data

M.Wt:
357.43
Formula:
C18H19N3O3S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
122320-73-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Agonist dose-response analyses of the Human PPAR gamma Assay.
By GAJANAN KATKAR on 12/07/2019
Application: Species: Human

PPAR gamma Assay was performed using manual dispensing and following the protocol described in this Technical Manual, using the Rosiglitazone. PPAR gamma reporter cells treated with 2,500 nM Rosiglitazone yielded an average RLU value with CV=7%, S/B = 162 and a corresponding Z’= 0.78.


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