Tabimorelin hemifumarate

Tocris Bioscience | Catalog # 2308

Potent, orally active ghrelin receptor agonist
Tocris Bioscience

Key Product Details

Description

Potent, orally active ghrelin receptor agonist

Alternative Names

NN 703
View all Ghrelin Receptor Agonists »

Product Description

Tabimorelin hemifumarate is a potent, orally active ghrelin receptor (GHS-R1a) agonist (Ki = 50 nM at human recombinant GHS-R1a). Stimulates GH release from rat pituitary cells with an EC50 value of 2.7 nM. Induces hyperphagia and adiposity in lean rats, but not in leptin signaling-deficient ZDF rats.

Product Specifications for Tabimorelin hemifumarate

Molecular Weight

586.73

Formula

C32H40N4O3.½C4H4O4

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamide hemifumarate

CAS Number

242143-80-2

PubChem ID

11981159

InChI Key

YQDJPWXYLLPOPW-LWTUVRFUSA-N

SMILES

[H]OC(=O)\C=C\C(=O)O[H].CNC(=O)[C@@H](CC1=CC=CC=C1)N(C)C(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)N(C)C(=O)\C=C\CC(C)(C)N.CNC(=O)[C@@H](CC1=CC=CC=C1)N(C)C(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)N(C)C(=O)\C=C\CC(C)(C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5.29 10 with gentle warming
DMSO 58.67 100

Preparing Stock Solutions for Tabimorelin hemifumarate

The following data is based on the product molecular weight 586.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.70 mL 8.52 mL 17.04 mL
5 mM 0.34 mL 1.70 mL 3.41 mL
10 mM 0.17 mL 0.85 mL 1.70 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for Tabimorelin hemifumarate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Tabimorelin hemifumarate

For research use only

Related Research Areas

Nutrition and Appetite
Obesity

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