Chemical Name: 1-Methylethyl (5-Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoate
Biological ActivityVery high affinity FP receptor agonist (Ki = 0.4 nM). Reduces intraocular pressure (IOP) in animal models of ocular hypertension and normal animals.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug.
Takagi et al.
Exp.Eye Res., 2004;78:767
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