Catalog Number: 5032
Alternate Names: GYKI 53773, LY 300164
Chemical Name: (8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
Biological Activity
Non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 (Cat. No. 1454). Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs.
    Czuczwar et al.
    Eur.J.Pharmacol., 1998;359:103
  2. The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of diazepam.
    Borowicz et al.
    Naunyn-Schmied.Arch.Pharmacol., 2000;361:629
  3. Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats.
    Belayev et al.
    J.Neurotrauma, 2001;18:1031
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