Non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466
(Cat. No. 1454). Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active.
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All Tocris products are intended for laboratory research use only.
LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs.
Czuczwar et al.
The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of diazepam.
Borowicz et al.
Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats.
Belayev et al.