Tamoxifen citrate

  ( 11 citations )    
Product Datasheet
Catalog Number:0999
Chemical Name:(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
Product Details
Citations (11)
Supplemental Products
Reviews
Biological Activity
Estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo. Also high affinity agonist at the membrane estrogen receptor GPER. Tamoxifen (Cat.No. 6432) is also available.
Technical Data
  • M.Wt:
    563.65
  • Formula:
    C26H29NO.C6H8O7
  • Solubility:
    Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    54965-24-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tamoxifen citrate include:

11 Citations: Showing 1 - 10
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  1. Tamoxifen synergizes with 4-(E)-{(4-hydroxyphenylimino)-methylbenzene, 1,2-diol} and 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, novel azaresveratrol analogs, in inhibiting the proliferation of breast cancer cells.
    Authors: Ronghe Et al.
    Oncotarget  2016;7:51747
  2. HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol.
    Authors: Bertrand Et al.
    Acta Pharm Sin B  2015;6:894
  3. DMH1 (4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy.
    Authors: Sheng Et al.
    J Urol  2015;5:330
  4. Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia.
    Authors: Nicholson Et al.
    PLoS One  2015;193:722
  5. Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone.
    Authors: Todd Et al.
    FEMS Immunol Med Microbiol  2015;10:e0140260
  6. Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line.
    Authors: Mansouri-Attia Et al.
    Biol Reprod  2014;91:100
  7. Role of GPR30 in mediating estradiol effects on acetylcholine release in the hippocampus.
    Authors: Gibbs Et al.
    Horm Behav  2014;66:339
  8. The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.
    Authors: Gutierrez Et al.
    J Biol Chem  2014;289:33568
  9. Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation.
    Authors: Antoon Et al.
    Cancer Biol Ther  2012;13:1026
  10. Estradiol shapes auditory processing in the adult brain by regulating inhibitory transmission and plasticity-associated gene expression.
    Authors: Tremere Et al.
    J Neurosci  2009;29:5949
  11. Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
    Authors: Wieland Et al.
    J Neurosci  2006;47:296
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