Catalog Number: 0999
Chemical Name: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
Biological Activity
Estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo. Also high affinity agonist at the membrane estrogen receptor GPER. Tamoxifen (Cat.No. 6432) is also available.
Technical Data
  • M.Wt:
    563.65
  • Formula:
    C26H29NO.C6H8O7
  • Solubility:
    Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    54965-24-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Non-steroidal anti-estrogens - receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells.
    Wakeling et al.
    J.Steroid.Biochem., 1984;20:111
  3. Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat.
    Mehta et al.
    Neuroendocrinology, 2003;77:44
  4. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.
    Thomas et al.
    Endocrinology, 2005;146:624
  5. Both the immunosuppressant SR31747 and the antioestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Δ8-Δ7 sterol isomerase.
    Paul et al.
    J.Pharmacol.Exp.Ther., 1998;285:1302
  6. Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake.
    Todorova et al.
    Cancer Chemother. Pharmacol., 2011;67:285
Tocris Small Molecules
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(Z)-4-Hydroxytamoxifen

3412  
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