Tamoxifen citrate

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Tamoxifen citrate | CAS No. 54965-24-1 | Estrogen and Related Receptor Modulators
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Description: Estrogen receptor partial agonist/antagonist

Chemical Name: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate

Purity: ≥99%

Product Details
Citations (11)
Supplemental Products

Biological Activity

Tamoxifen citrate is an estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo. Also high affinity agonist at the membrane estrogen receptor GPER. Tamoxifen (Cat. No. 6432) is also available.

Technical Data

Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.

Product Datasheets

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⚠ WARNING: This product can expose you to chemicals including Tamoxifen citrate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Tamoxifen citrate

The citations listed below are publications that use Tocris products. Selected citations for Tamoxifen citrate include:

11 Citations: Showing 1 - 10

  1. Tamoxifen synergizes with 4-(E)-{(4-hydroxyphenylimino)-methylbenzene, 1,2-diol} and 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, novel azaresveratrol analogs, in inhibiting the proliferation of breast cancer cells.
    Authors: Ronghe Et al.
    Oncotarget  2016;7:51747
  2. HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol.
    Authors: Bertrand Et al.
    Acta Pharm Sin B  2015;6:894
  3. DMH1 (4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy.
    Authors: Sheng Et al.
    J Urol  2015;5:330
  4. Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia.
    Authors: Nicholson Et al.
    PLoS One  2015;193:722
  5. Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone.
    Authors: Todd Et al.
    FEMS Immunol Med Microbiol  2015;10:e0140260
  6. Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line.
    Authors: Mansouri-Attia Et al.
    Biol Reprod  2014;91:100
  7. Role of GPR30 in mediating OE effects on acetylcholine release in the hippocampus.
    Authors: Gibbs Et al.
    Horm Behav  2014;66:339
  8. The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.
    Authors: Gutierrez Et al.
    J Biol Chem  2014;289:33568
  9. Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation.
    Authors: Antoon Et al.
    Cancer Biol Ther  2012;13:1026
  10. OE shapes auditory processing in the adult brain by regulating inhibitory transmission and plasticity-associated gene expression.
    Authors: Tremere Et al.
    J Neurosci  2009;29:5949


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