Tankyrase binding protein 1 Antibody

Name: Tankyrase binding protein 1 Antibody
Brand: Novus Biologicals
SKU: NB100-68249
Price: 459 USD
Availability: InStock

Novus Biologicals | Catalog # NB100-68249

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Human

Applications

Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

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Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 1679 and 1729 of human tankyrase 1-binding protein of 182 kDa using the numbering given in entry NP_203754.2 (GeneID 85456).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Tankyrase binding protein 1 Antibody

Western Blot: Tankyrase binding protein 1 Antibody [NB100-68249]

Western Blot: Tankyrase binding protein 1 Antibody [NB100-68249] - Detection of Human TAB182 by Western Blot. Samples: Whole cell lysate (5, 15 and 50 ug) from HeLa cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-TAB182 antibody NB100-68249 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Immunoprecipitation: Tankyrase binding protein 1 Antibody [NB100-68249]

Immunoprecipitation: Tankyrase binding protein 1 Antibody [NB100-68249] - Detection of human TAB182 (Tankyrase binding protein 1) by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-TAB182 antibody NB100-68249 used for IP at 6 ug per reaction. TAB182 was also immunoprecipitated by rabbit anti-TAB182 antibodies NB100-68247 and NB100-68248. For blotting immunoprecipitated TAB182, NB100-68249 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Applications for Tankyrase binding protein 1 Antibody

Application

Recommended Usage

Immunoprecipitation

2-10 ug/mg lysate

Western Blot

1:2000-1:10000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Tankyrase binding protein 1

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

Alternate Names

KIAA1741TAB182FLJ45975,182 kDa tankyrase-1-binding protein, tankyrase 1 binding protein 1, 182kDa, tankyrase 1-binding protein of 182 kDa

Entrez Gene IDs

85456 (Human)

Gene Symbol

TNKS1BP1

UniProt

NP_203754.2 (Human)

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Product Specific Notices for Tankyrase binding protein 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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