TASP 0277308

Key Product Details

Product Description

TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P₁) receptor antagonist (IC₅₀ = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC₅₀ = 1.1-1.6 nM), HUVEC cell proliferation (IC₅₀ = 3-3.6 nM) and suppresses angiogenesis in vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECs in vitro and reverses or impairs the development of arthritis or mechano-allodynia.

Product Specifications for TASP 0277308

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TASP 0277308

The following data is based on the product molecular weight 539.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	37.07 mL	185.36 mL	370.73 mL
0.25 mM	7.41 mL	37.07 mL	74.15 mL
0.5 mM	3.71 mL	18.54 mL	37.07 mL
2.5 mM	0.74 mL	3.71 mL	7.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Fujii Blocking S1P interaction with S1P₁ receptor by a novel competitive S1P₁-selective antagonist inhibits angiogenesis. Biochem.Biophys.Res.Commun. 2012 PMID: 22387544
• Fujii Amelioration of collagen-induced arthritis by a novel S1P₁ antagonist with immunomodulatory activities. J.Immunol. 2012 PMID: 22131329

Product Documents for TASP 0277308