TC-G 1004

Tocris Bioscience | Catalog # 4407

Potent and selective A2A antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective A2A antagonist
View all Adenosine A2a Receptor Antagonists »

Product Description

TC-G 1004 is a potent antagonist of adenosine A2A receptors; displays >100-fold selectivity for A2A over A1 receptors (Ki values are 0.44 and 85 nM respectively). Potentiates L-DOPA-induced rotational behavior in 6-OHDA-lesioned rats.

Product Specifications for TC-G 1004

Molecular Weight

421.50

Formula

C22H27N7O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxy-1-piperidinyl)-2-pyridinyl]-4-pyrimidinyl]acetamide

CAS Number

1061747-72-5

PubChem ID

25074316

InChI Key

JENSDTKXNVHSSN-UHFFFAOYSA-N

SMILES

CC1=CC(C)=NN1C2=NC(C3=CC=CC(N4CCC(OC)CC4)=N3)=CC(NC(C)=O)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 42.15 100
DMSO 42.15 100

Preparing Stock Solutions for TC-G 1004

The following data is based on the product molecular weight 421.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.86 mL 23.72 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.19 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for TC-G 1004

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TC-G 1004

For research use only

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