TC-G 1008

Catalog # Availability Size / Price Qty
5355/10
5355/50
Orphan 7-TM Receptor Agonists Small Molecule
1 Image
Description: Potent and selective GPR39 agonist

Chemical Name: N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide

Purity: ≥98%

Product Details
Citations (4)
Supplemental Products
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Biological Activity

Potent and selective GPR39 agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). Selective over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Increases GLP-1 levels in vitro and in vivo. Orally bioavailable.

Technical Data

M.Wt:
418.9
Formula:
C18H19ClN6O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1621175-65-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of 2-pyridylpyrimidines as the first orally bioavailable GPR39 agonists.
    Peukert et al.
    ACS Med.Chem.Lett., 2014;5:1114

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Citations for TC-G 1008

The citations listed below are publications that use Tocris products. Selected citations for TC-G 1008 include:

4 Citations: Showing 1 - 4

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