TRPM8 channel blocker. Inhibits icilin
-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC50
= 53 nM).
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All Tocris products are intended for laboratory research use only.
Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.
Tamayo et al.