TC-N 1752

Tocris Bioscience | Catalog # 4435

NaV channel blocker
Tocris Bioscience

Key Product Details

Description

NaV channel blocker
View all Voltage-gated Sodium Channel Blockers »

Product Description

TC-N 1752 is a human NaV channel inhibitor (IC50 values are 0.17, 0.3, 0.4, 1.1 and 1.6 μM at hNaV1.7, hNaV1.3, hNaV1.4, hNaV1.5 and hNav1.9 respectively). Also inhibits tetrodotoxin-sensitive sodium channels. Displays analgesic efficacy in the formalin pain model.

Product Specifications for TC-N 1752

Molecular Weight

516.52

Formula

C25H27F3N6O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide

CAS Number

1211866-85-1

PubChem ID

53361524

InChI Key

QLKAFHZJICDACE-UHFFFAOYSA-N

SMILES

CC(C(NC(C)=O)=CC=C4)=C4NC1=NC=NC(N2CCC(OCC3=CC=C(OC(F)(F)F)C=C3)CC2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 5.17 10
DMSO 51.65 100

Preparing Stock Solutions for TC-N 1752

The following data is based on the product molecular weight 516.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.68 mL 19.36 mL
5 mM 0.39 mL 1.94 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for TC-N 1752

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TC-N 1752

For research use only

Related Research Areas

Ion Channels and Regulators

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