Catalog Number: 4435
Chemical Name: N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide
Biological Activity
Human NaV channel inhibitor (IC50 values are 0.17, 0.3, 0.4, 1.1 and 1.6 μM at hNaV1.7, hNaV1.3, hNaV1.4, hNaV1.5 and hNav1.9 respectively). Also inhibits tetrodotoxin-sensitive sodium channels. Displays analgesic efficacy in the formalin pain model.
Technical Data
  • M.Wt:
    516.52
  • Formula:
    C25H27F3N6O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    1211866-85-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.
    Bregman et al.
    J.Med.Chem., 2011;54:4427
  2. Biophysical and pharmacological characterization of Nav1.9 voltage dependent sodium channels stably expressed in HEK-293 cells.
    Lin et al.
    PLoS One., 2016;11
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TC-N 1752 include:

1 Citations: Showing 1 - 1

  1. Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery.
    Authors: Curtright Et al.
    PLoS One 2015;10:e0116766

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