TCB-2

  ( 5 citations )    
Product Datasheet
Catalog Number:2592
Chemical Name:(4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide
Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity
High affinity 5-HT2A receptor agonist (Ki values are 0.73 and 0.75 nM for rat and human receptors respectively). Potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors (EC50 = 36 nM). Induces head twitches and hypothermia in mice following i.p. adminitration.
Technical Data
  • M.Wt:
    353.05
  • Formula:
    C11H14BrNO2.HBr
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    912342-28-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for TCB-2 include:

5 Citations: Showing 1 - 5
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  1. The 5-HT2A receptor potassium-chloride cotransporter 2 signaling pathway in a rat incision pain model.
    Authors: Dong Et al.
    Exp Ther Med  2016;12:3583
  2. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    PLoS One  2015;3:e00103
  3. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  4. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens.
    Authors: Goda Et al.
    Psychopharmacology (Berl)  2013;228:271
  5. Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.
    Authors: Niebert Et al.
    EMBO Mol Med  2011;6:e21395

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