TCB-2

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2592/10
2592/50
TCB-2 | CAS No. 912342-28-0 | 5-HT2A Receptor Agonists
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Description: High affinity and potent 5-HT2A agonist

Chemical Name: (4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide

Purity: ≥99%

Product Details
Citations (7)
Supplemental Products
Reviews (1)

Biological Activity

High affinity 5-HT2A receptor agonist (Ki values are 0.73 and 0.75 nM for rat and human receptors respectively). Potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors (EC50 = 36 nM). Induces head twitches and hypothermia in mice following i.p. administration.

Technical Data

M.Wt:
353.05
Formula:
C11H14BrNO2.HBr
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
912342-28-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TCB-2

The citations listed below are publications that use Tocris products. Selected citations for TCB-2 include:

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5-HT has a potential for relaxant
By Anonymous on 02/18/2020
Application: Species: Rat

TCB-2 (5-HT2A)(0.0001 mol/L)

PMID: 25692021

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