High affinity 5-HT2A
receptor agonist (Ki
values are 0.73 and 0.75 nM for rat and human receptors respectively). Potently stimulates IP3
accumulation in NIH3T3 cells stably expressing rat 5-HT2A
= 36 nM). Induces head twitches and hypothermia in mice following i.p. adminitration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists.
McLean et al.
The serotonin 5-HT2A receptor agonist TCB-2: a behavioral and neurophysiological analysis.
Fox et al.
Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.
Niebert et al.
PLoS One, 2011;6:e21395
The citations listed below are publications that use Tocris products. Selected citations for TCB-2 include:
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