Key Product Details

Species Reactivity

Human

Applications

Block/Neutralize, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Serum

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # BMA031

Format

BSA Free
View all TCR alpha/beta Primary Antibodies »

Product Specifications

Immunogen

The original antibody was generated by immunizing mice with human perihperal blood T-lymphocytes.

Specificity

This antibody reacts with surface receptors on all alpha-beta TCR alpha/beta bearing cells, but does not react with receptors on gamma-delta T cells. TCR alpha/beta-alphabeta is expressed by the majority of mature CD3+ T cells.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Scientific Data Images for TCR alpha/beta Antibody (BMA031) - Chimeric - BSA Free

TCR alpha/beta Antibody (BMA031) - Chimeric - BSA Free TCR alpha/beta Antibody (BMA031) - Chimeric - BSA Free

Immunocytochemistry/ Immunofluorescence: TCR alpha/beta Antibody (BMA031) - Chimeric - BSA Free [NBP3-43550] -

Immunocytochemistry/ Immunofluorescence: TCR alpha/beta Antibody (BMA031) - Chimeric - BSA Free [NBP3-43550] - Immunofluorescence analysis of paraformaldehyde-fixed Jurkat cells on coverslips stained with NBP3-43550 (1:100 dilution) for 1h followed by Alexa Fluor® 488 secondary antibody (1:1000 dilution), showing membrane staining. The nuclear stain is DAPI (blue). Panels show, from left-right, top-bottom, NBP3-43550, DAPI, merged channels and an isotype control. The isotype control was an unknown specificity antibody followed by staining with Alexa Fluor® 488 secondary antibody.

Applications for TCR alpha/beta Antibody (BMA031) - Chimeric - BSA Free

Application
Recommended Usage

Serum

FACS

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TCR alpha/beta

The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.

Alternate Names

C), D, FLJ22602, J, MGC117436, MGC22624, MGC23964, MGC71411, T cell receptor alpha locus, T-cell antigen receptor, alpha polypeptide, T-cell receptor, alpha (V, TCRA, TCRD, TRA

Gene Symbol

TRA

Additional TCR alpha/beta Products

Product Documents for TCR alpha/beta Antibody (BMA031) - Chimeric - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TCR alpha/beta Antibody (BMA031) - Chimeric - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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