Tetanus Toxin Synthetic Peptide

Novus Biologicals | Catalog # NBP2-62536

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Key Product Details

Source

Synthetic

Accession Number

P04958

Applications

ELISA
View all Tetanus Toxin Small Molecules and Peptides »

Product Specifications

Description

Synthetic tetanus toxin peptide is a 15 amino acid peptide corresponding to amino acid residues 1300-1314 located at the C-terminus of the Clostridium tetani tetanus toxin heavy chain according to entrez protein accession number CAA28033. Amino Acid Sequence: CDWYFVPTDEGWTND

Protein / Peptide Type

Synthetic Peptide

Formulation, Preparation, and Storage

NBP2-62536
Preparation Method Solid phase synthesis
Preservative No Preservative
Concentration 1 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: Tetanus Toxin

Tetanus toxin, a member of the peptidase M27 family of proteins, is produced by the anaerobic spore-forming bacteria Clostridium tetani as a single-chain polypeptide that is 1315 amino acids (aa) in length. The protein is subsequently cleaved by an endogenous protease to yield the 52 kDa tetanus toxin light chain (TeNT-LC), which is 457 aa in length, and the 98 kDa tetanus toxin heavy chain that is 858 aa long. The light and heavy chains are linked by a disulfide bridge and are non-toxic after separation. Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neural synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 76-Gln-|-Phe-77 bond of synaptobrevin-2.

Alternate Names

Tentoxylysin

Entrez Gene IDs

CAA28033 (C. tetani)

Gene Symbol

TETX

UniProt

P04958 (C. tetani)

Additional Tetanus Toxin Products

Product Documents for Tetanus Toxin Synthetic Peptide

Certificate of Analysis

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Product Specific Notices for Tetanus Toxin Synthetic Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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