Catalog Number: 2532
Chemical Name: (3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-aspartic acid
Biological Activity
Potent and selective glial glutamate transporter EAAT1 and EAAT2 inhibitor (IC50 values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3 respectively). Has no effect on EAAT4 and EAAT5, or a wide range of neuronal receptors and transporters. Attenuates glutamate-stimulated intracellular Na+ elevation in astrocytes in vitro (IC50 = 43 nM). Induces severe convulsions in vivo.
Technical Data
  • M.Wt:
    426.35
  • Formula:
    C19H17F3N2O6
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    480439-73-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under license from Suntory Ltd.
Background References
  1. Effects of a novel glutamate transporter blocker, (2S, 3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy}aspartate (TFB-TBOA), on activities of hippocampal neurons.
    Tsukada et al.
    Neuropharmacology, 2005;48:479
  2. Physical and functional interaction of NCX1 and EAAC1 transporters leading to glutamate-enhanced ATP production in brain mitochondria.
    Magi et al.
    PLoS One, 2012;7:e34015
  3. Inhibitory effects of (2S, 3S)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (TFB-TBOA) on the astrocytic sodium responses to glutamate.
    Bozzo and Chatton
    Brain Res., 2010;1316
  4. Elucidation of glutamate transporter functions using selective inhibitors.
    Shimamoto and Shigeri
    CNS Agents Med.Chem., 2006;6:59
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TFB-TBOA include:

7 Citations: Showing 1 - 7
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  1. Structure and allosteric inhibition of excitatory amino acid transporter 1.
    Authors: Canul-Tec
    Nature 2017;
  2. High-frequency voltage oscillations in cultured astrocytes.
    Authors: Fleischer Et al.
    PLoS One 2015;3
  3. The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
    Authors: Obba Et al.
    Mol Pain 2015;11:1114
  4. Paclitaxel induces acute pain via directly activating toll like receptor 4.
    Authors: Yan Et al.
    Physiol Rep 2015;11:10
  5. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
    Authors: Ivanov Et al.
    J Cereb Blood Flow Metab 2014;34:397
  6. Low micromolar Ba(2+) potentiates glutamate transporter current in hippocampal astrocytes.
    Authors: Afzalov Et al.
    Front Cell Neurosci 2013;7:135
  7. Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at μ-opioid receptor-expressing glia.
    Authors: Zou Et al.
    Brain 2011;134:3616

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