Catalog # Availability Size / Price Qty
TFB-TBOA | CAS No. 480439-73-4 | Glutamate (EAAT) Transporter Inhibitors
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Description: High affinity EAAT1 and EAAT2 blocker

Chemical Name: (3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-aspartic acid

Purity: ≥98%

Product Details
Citations (12)

Biological Activity

TFB-TBOA is a potent and selective glial glutamate transporter EAAT1 and EAAT2 inhibitor (IC50 values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3 respectively). Exhibits selectivity for EAAT1 and EAAT2 over EAAT4 and EAAT5, or a wide range of neuronal receptors and transporters. Attenuates glutamate-stimulated intracellular Na+ elevation in astrocytes in vitro (IC50 = 43 nM). Induces severe convulsions in vivo.

Technical Data

Soluble to 50 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TFB-TBOA

The citations listed below are publications that use Tocris products. Selected citations for TFB-TBOA include:

12 Citations: Showing 1 - 10

  1. Extracellular S100β Disrupts Bergman Glia Morphology and Synaptic Transmission in Cerebellar Purkinje Cells.
    Authors: Belozor Et al.
    Brain Sci  2019;9
  2. M�ller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors.
    Authors: Zhang Et al.
    Cell Rep  2019;27:2871
  3. Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model.
    Authors: Rocchio Et al.
    Cell Death Dis  2019;10:24
  4. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
    Authors: Chai Et al.
    Neuron  2017;95:531
  5. Structure and allosteric inhibition of excitatory amino acid transporter 1.
    Authors: Canul-Tec
    Nature  2017;
  6. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
    Authors: O'Donnell Et al.
    J Neurosci  2016;36:7109
  7. High-frequency voltage oscillations in cultured astrocytes.
    Authors: Fleischer Et al.
    PLoS One  2015;3
  8. The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
    Authors: Obba Et al.
    Mol Pain  2015;11:1114
  9. PacT. induces acute pain via directly activating toll like receptor 4.
    Authors: Yan Et al.
    Physiol Rep  2015;11:10
  10. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
    Authors: Ivanov Et al.
    J Cereb Blood Flow Metab  2014;34:397


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