TFB-TBOA

  ( 7 citations )    
Product Datasheet
Catalog Number:2532
Chemical Name:(3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-aspartic acid
Product Details
Citations (7)
Reviews
Biological Activity
Potent and selective glial glutamate transporter EAAT1 and EAAT2 inhibitor (IC50 values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3 respectively). Has no effect on EAAT4 and EAAT5, or a wide range of neuronal receptors and transporters. Attenuates glutamate-stimulated intracellular Na+ elevation in astrocytes in vitro (IC50 = 43 nM). Induces severe convulsions in vivo.
Technical Data
  • M.Wt:
    426.35
  • Formula:
    C19H17F3N2O6
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    480439-73-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under license from Suntory Ltd.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for TFB-TBOA include:

7 Citations: Showing 1 - 7
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  1. Structure and allosteric inhibition of excitatory amino acid transporter 1.
    Authors: Canul-Tec
    Nature  2017;
  2. High-frequency voltage oscillations in cultured astrocytes.
    Authors: Fleischer Et al.
    PLoS One  2015;3
  3. The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
    Authors: Obba Et al.
    Mol Pain  2015;11:1114
  4. Paclitaxel induces acute pain via directly activating toll like receptor 4.
    Authors: Yan Et al.
    Physiol Rep  2015;11:10
  5. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
    Authors: Ivanov Et al.
    J Cereb Blood Flow Metab  2014;34:397
  6. Low micromolar Ba(2+) potentiates glutamate transporter current in hippocampal astrocytes.
    Authors: Afzalov Et al.
    Front Cell Neurosci  2013;7:135
  7. Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at μ-opioid receptor-expressing glia.
    Authors: Zou Et al.
    Brain  2011;134:3616

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