TFLLR-NH2

  ( 9 citations )    
Product Datasheet
Catalog Number:1464
Chemical Name:
Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity
Peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo.

Control Peptide also available.

Technical Data
  • M.Wt:
    647.82
  • Formula:
    C31H53N9O6
  • Sequence:
    TFLLR

    (Modifications: Arg-5 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    197794-83-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for TFLLR-NH2 include:

9 Citations: Showing 1 - 9
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  1. PAR1?mediated c?Jun activation promotes heat stress?induced early stage apoptosis of human umbilical vein endothelial cells.
    Authors: Zhang Et al.
    Mol Med Rep  2017;15:2595
  2. Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4.
    Authors: Wang
    Proc Natl Acad Sci U S A  2017;114(41):10948
  3. Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
    Authors: Carlsen and Perrier
    Front Neural Circuits  2014;8:60
  4. Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation.
    Authors: Chen Et al.
    Endocrinology  2012;9:142
  5. Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
    Authors: Wang Et al.
    J Neuroinflammation  2012;5:ra26
  6. Thrombin activity associated with neuronal damage during acute focal ischemia.
    Authors: Chen Et al.
    J Neurosci  2012;32:7622
  7. An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
    Authors: Gómez-Gonzalo Et al.
    PLoS Biol  2010;8:e1000352
  8. Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
    Authors: Vellani Et al.
    Mol Pain  2010;6:61
  9. The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion.
    Authors: Fujimoto Et al.
    BMC Cancer  2010;10:443

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