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Description: PAR1-activating peptide

Purity: ≥95%

Product Details
Citations (11)
Supplemental Products
Reviews (2)

Biological Activity

TFLLR-NH2 is a peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo.

Control Peptide also available.

Technical Data


(Modification: Arg-5 = C-terminal amide)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for TFLLR-NH2

The citations listed below are publications that use Tocris products. Selected citations for TFLLR-NH2 include:

11 Citations: Showing 1 - 10

  1. Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing.
    Authors: Zhang Et al.
    J Tissue Eng  2019;10:2041731418820030
  2. Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-β.
    Authors: M?ller Et al.
    Curr Biol  2018;28:3481
  3. PAR1?mediated c?Jun activation promotes heat stress?induced early stage apoptosis of human umbilical vein endothelial cells.
    Authors: Zhang Et al.
    Mol Med Rep  2017;15:2595
  4. Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4.
    Authors: Wang
    Proc Natl Acad Sci U S A  2017;114(41):10948
  5. Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
    Authors: Carlsen and Perrier
    Front Neural Circuits  2014;8:60
  6. Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation.
    Authors: Chen Et al.
    Endocrinology  2012;9:142
  7. Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
    Authors: Wang Et al.
    J Neuroinflammation  2012;5:ra26
  8. Thrombin activity associated with neuronal damage during acute focal ischemia.
    Authors: Chen Et al.
    J Neurosci  2012;32:7622
  9. An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
    Authors: Gómez-Gonzalo Et al.
    PLoS Biol  2010;8:e1000352
  10. Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
    Authors: Vellani Et al.
    Mol Pain  2010;6:61


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Reviews for TFLLR-NH2

Average Rating: 5 (Based on 2 Reviews)

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Effect of TFLLR-NH2 on PLCbeta activity in HASMCs
By Anonymous on 04/06/2021
Species: Human

Effect of TFLLR-NH2 on PLCbeta activity in HASMCs

Effect of TFLLR-NH2 on TGFb1 release by platelets
By Anonymous on 12/16/2018

5uM TFLLR-NH2 was treated on platelets and the TGFb1 release was measured by ELISA.

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