Catalog Number: 1464
Biological Activity
Peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo.

Control Peptide also available.

Technical Data
  • M.Wt:
    647.82
  • Formula:
    C31H53N9O6
  • Sequence:
    TFLLR

    (Modifications: Arg-5 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    197794-83-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism.
    de Garavilla et al.
    Br.J.Pharmacol., 2001;133:975
  2. Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides.
    Hollenberg et al.
    Can.J.Physiol.Pharmacol., 1997;75:832
  3. Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.
    Kawabata et al.
    Life Sci., 2000;67:2521
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TFLLR-NH2 include:

8 Citations: Showing 1 - 8
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  1. Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4.
    Authors: Wang
    Proc Natl Acad Sci U S A 2017;114(41):10948
  2. Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
    Authors: Carlsen and Perrier
    Front Neural Circuits 2014;8:60
  3. Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation.
    Authors: Chen Et al.
    Endocrinology 2012;9:142
  4. Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
    Authors: Wang Et al.
    J Neuroinflammation 2012;5:ra26
  5. Thrombin activity associated with neuronal damage during acute focal ischemia.
    Authors: Chen Et al.
    J Neurosci 2012;32:7622
  6. An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
    Authors: Gómez-Gonzalo Et al.
    PLoS Biol 2010;8:e1000352
  7. Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
    Authors: Vellani Et al.
    Mol Pain 2010;6:61
  8. The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion.
    Authors: Fujimoto Et al.
    BMC Cancer 2010;10:443
Tocris Peptides
Description Application Cat# Citations Images  

RLLFT-NH2

3393 1  
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