Catalog Number: 1464
Biological Activity
Peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo. Control Peptide RLLFT-NH2 (Cat. No. 3393) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Arg-5 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism.
    de Garavilla et al.
    Br.J.Pharmacol., 2001;133:975
  2. Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides.
    Hollenberg et al.
    Can.J.Physiol.Pharmacol., 1997;75:832
  3. Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.
    Kawabata et al.
    Life Sci., 2000;67:2521
Tocris Peptides
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