TGF-beta Antibody (TGFB/510)

Novus Biologicals | Catalog # NBP3-07708

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Bovine, Canine, Hamster, Monkey

Applications

ELISA, Functional Assay

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # TGFB/510
View all TGF-beta Primary Antibodies »

Product Specifications

Immunogen

Full length recombinant human TGF-beta protein

Localization

Cytoplasm and extracellular (secreted)

Specificity

This monoclonal antibody recognizes TGF beta 1, 2 and 3. TGFs inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells. Most breast lesions, benign and malignant, involve abnormal proliferation and altered architecture of stromal and/or epithelial elements.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Theoretical MW

13 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP3-08739)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.

Applications for TGF-beta Antibody (TGFB/510)

Application
Recommended Usage

ELISA

0.1-0.4 ug/ml
Application Notes
ELISA: 0.1-0.4ug/ml - Detection. ELISA: 0.1-0.4ug/ml - Detection, 2-8ug/ml - Capture.
Functional Assay: Order Ab without BSA/Azide.
Optimal dilution for a specific application should be determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: TGF-beta

TGF-beta 1 (Transforming Growth Factor beta 1) is a pleiotrophic cytokine that regulates immune function, proliferation, and epithelial-mesenchymal transition. TGF-beta 1 associates with LAP to form a latent complex. It can be is activated from latency by plasmin, matrix metalloproteases, thrombospondin 1, and a subset of integrins. TGF-beta 1 signals through complexes of TGF-beta RII with TGF-beta RI/ALK-5 or ALK-1. TGF-beta signaling is modulated by the accessory receptors TGF-beta RIII/Betaglycan and Endoglin/CD105.

Long Name

Transforming Growth Factor beta

Alternate Names

TGFbeta

Gene Symbol

TGFB1

UniProt

P10600, P61812, P01137 (Human)

Additional TGF-beta Products

Product Documents for TGF-beta Antibody (TGFB/510)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for TGF-beta Antibody (TGFB/510)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

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Associated Pathways

Th17 Differentiation Pathway Th17 Differentiation Pathway Thumbnail