TGF-beta Antibody (TGFB/510) - Azide and BSA Free

Novus Biologicals | Catalog # NBP3-08739

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Bovine, Canine, Hamster, Monkey

Applications

ELISA, Functional Assay

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # TGFB/510

Format

Azide and BSA Free
View all TGF-beta Primary Antibodies »

Product Specifications

Immunogen

Full length recombinant human TGF-beta protein

Localization

Cytoplasm and extracellular (secreted)

Specificity

This monoclonal antibody recognizes TGF beta 1, 2 and 3. TGFs inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells. Most breast lesions, benign and malignant, involve abnormal proliferation and altered architecture of stromal and/or epithelial elements.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Theoretical MW

13 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

1.0 mg/ml of antibody purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS WITHOUT BSA & azide. Also available at 200 ug/ml WITH BSA & azide (NBP3-07708).

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.

Applications for TGF-beta Antibody (TGFB/510) - Azide and BSA Free

Application
Recommended Usage

ELISA

0.1-0.4 ug/ml
Application Notes
Functional Assay: Order antibody without BSA/Azide

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -80C. Avoid freeze-thaw cycles.

Background: TGF-beta

TGF-beta 1 (Transforming Growth Factor beta 1) is a pleiotrophic cytokine that regulates immune function, proliferation, and epithelial-mesenchymal transition. TGF-beta 1 associates with LAP to form a latent complex. It can be is activated from latency by plasmin, matrix metalloproteases, thrombospondin 1, and a subset of integrins. TGF-beta 1 signals through complexes of TGF-beta RII with TGF-beta RI/ALK-5 or ALK-1. TGF-beta signaling is modulated by the accessory receptors TGF-beta RIII/Betaglycan and Endoglin/CD105.

Long Name

Transforming Growth Factor beta

Alternate Names

TGFbeta

Gene Symbol

TGFB1

Additional TGF-beta Products

Product Documents for TGF-beta Antibody (TGFB/510) - Azide and BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for TGF-beta Antibody (TGFB/510) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

No product specific FAQs exist for this product.

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Associated Pathways

Th17 Differentiation Pathway Th17 Differentiation Pathway Thumbnail