Chemical Name: (3α,5α)-3,21-Dihydroxypregnan-20-one
Biological ActivityTHDOC is a positive modulator of GABAA receptors. Potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro. Endogenous neurosteroid.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes.
Villumsen et al.
Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors.
Adams et al.
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