Chemical Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
Biological ActivityPotent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.
Yuzwa et al.
Pharmacological inhibition of O-GlcNAcase enhances autophagy in brain through an mTOR-independent pathway
Zhu et al.
ACS Chem.Neurosci., 2018;9:1366
Citations for Thiamet G
The citations listed below are publications that use Tocris products. Selected citations for Thiamet G include:
3 Citations: Showing 1 - 3
O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis.
Authors: Taparra Et al.
J Clin Invest 2018;128:4924
Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells.
Authors: Hayakawa Et al.
J Biol Chem 2013;288:17099
Excess of O-linked N-acetylglucosamine modifies human pluripotent stem cell differentiation.
Authors: Maury Et al.
Stem Cell Res 2013;11:926
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