Thiamet G

Catalog # Availability Size / Price Qty
4390/10
Hydrolase Inhibitors Small Molecule
1 Image
Description: Potent O-GlcNAcase inhibitor

Chemical Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol

Product Details
Citations (3)
Reviews

Biological Activity

Potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.

Technical Data

M.Wt:
248.3
Formula:
C9H16N2O4S
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store at -20°C
CAS No:
1009816-48-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Thiamet G

The citations listed below are publications that use Tocris products. Selected citations for Thiamet G include:

3 Citations: Showing 1 - 3

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