Catalog Number: 4390
Chemical Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
Biological Activity
Potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Orally bioavailable and blood brain barrier permeable.
Technical Data
  • M.Wt:
    248.3
  • Formula:
    C9H16N2O4S
  • Solubility:
    Soluble to 50 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    1009816-48-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.
    Yuzwa et al.
    Nat.Chem.Biol., 2008;4:483
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Thiamet G include:

1 Citations: Showing 1 - 1

  1. Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells.
    Authors: Hayakawa Et al.
    J Biol Chem 2013;288:17099

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