Thrombomodulin/BDCA-3 Antibody (4D8.2C6) - Azide and BSA Free

Novus Biologicals | Catalog # NBP2-80978

Novus Biologicals
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Key Product Details

Species Reactivity

Mouse

Applications

Western Blot, Flow Cytometry, CyTOF-ready

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG1 Clone # 4D8.2C6

Format

Azide and BSA Free
View all Thrombomodulin/BDCA-3 Primary Antibodies »

Product Specifications

Immunogen

Two synthetic peptides made to internal portions of the mouse Thrombomodulin protein (between residues 25-150 and 400-550) [UniProt P07204]

Clonality

Monoclonal

Host

Rat

Isotype

IgG1

Applications for Thrombomodulin/BDCA-3 Antibody (4D8.2C6) - Azide and BSA Free

Application
Recommended Usage

Flow Cytometry

2 ug / 1 million cells

Western Blot

2 ug/ml

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Thrombomodulin/BDCA-3

Encoded by the THBD gene, Thrombomodulin is also known as CD141 antigen. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin (aa 31 to 167), EGF-like (aa 240 to 280, aa 283 to 323, aa 324 to 362, aa 364 to 404, aa 405 to 439, and aa 440 to 480), transmembrane (aa 518 to 541) and cytoplasmic (aa 542 to 577) (1). The R&D Systems rmTHBD consists of aa 17 to 517, corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. It functions as a cell surface receptor and an essential cofactor for active thrombin, which in turn activates protein C and thrombin-activatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2). Activated protein C (APC), facilitated by protein S, degrades coagulation factors Va and VIIIa, which are required for thrombin activation. Activated CPB2 cleaves basic C-terminal amino acid residues of its substrates, including fibrin, preventing the conversion of plasminogen to plasmin. In addition, THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer (5). For example, increased serum levels of THBD, due to protease cleavage, have been associated with smoking, cardiac surgery, atherosclerosis, liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis.

Alternate Names

BDCA-3, BDCA3, CD141, Fetomodulin, THBD, THRM

Gene Symbol

THBD

Additional Thrombomodulin/BDCA-3 Products

Product Documents for Thrombomodulin/BDCA-3 Antibody (4D8.2C6) - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for Thrombomodulin/BDCA-3 Antibody (4D8.2C6) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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