Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
Biological ActivityPROTAC comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand, pomalidomide (Cat. No. 6302). Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines. Negative control TL 13-27 (Cat. No. 6525) is also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader.
Huang et al.
Cell Chem.Biol., 2018;25:88
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for TL 12-186
There are currently no reviews for this product. Be the first to review TL 12-186 and earn rewards!
Have you used TL 12-186?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image