TL 12-186

Tocris Bioscience | Catalog # 6524

Multikinase Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Multikinase Degrader (PROTAC®)
View all Active Degraders »

Product Description

TL 12-186 is a degrader (PROTAC®) comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand, pomalidomide (Cat. No. 6302). Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines.

Negative control TL 13-27 (Cat. No. 6525) is also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for TL 12-186

Molecular Weight

931.46

Formula

C44H51ClN10O9S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

CAS Number

2250025-88-6

PubChem ID

134812843

InChI Key

YNGWQHGVASHCBK-UHFFFAOYSA-N

SMILES

O=C1C(CCC(N1)=O)N2C(C3=C(C2=O)C=CC=C3NCC(NCCOCCOCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC(NC7=C(C=CC=C7)S(=O)(C(C)C)=O)=C(C=N6)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 93.15 100

Preparing Stock Solutions for TL 12-186

The following data is based on the product molecular weight 931.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.07 mL 5.37 mL 10.74 mL
5 mM 0.21 mL 1.07 mL 2.15 mL
10 mM 0.11 mL 0.54 mL 1.07 mL
50 mM 0.02 mL 0.11 mL 0.21 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for TL 12-186

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TL 12-186

For research use only

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