TL4-12

Catalog # Availability Size / Price Qty
5910/10
5910/50
Cat.No. 5910 - TL4-12 | C25H27F3N6O2 | CAS No. 1620820-12-3
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Description: Potent MAP4K2 (GCK) inhibitor

Chemical Name: 4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide

Purity: ≥98%

Product Details
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Biological Activity

Potent MAP4K2 (GCK) inhibitor (IC50 = 37 nM). Exhibits >70-fold selectivity for MAP4K2 over TAK1 (IC50 = 2.7 μM for TAK1). Inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation, in vitro.

Technical Data

M.Wt:
500.53
Formula:
C25H27F3N6O2
Solubility:
Soluble to 20 mM in DMSO and to 20 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1620820-12-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Product Datasheets

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