TL4-12

Key Product Details

Product Description

TL4-12 is a potent MAP4K2 (GCK) inhibitor (IC₅₀ = 37 nM). Exhibits >70-fold selectivity for MAP4K2 over TAK1 (IC₅₀ = 2.7 μM for TAK1). Inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation, in vitro.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Product Specifications for TL4-12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TL4-12

The following data is based on the product molecular weight 500.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.99 mL	49.95 mL	99.89 mL
1 mM	2.00 mL	9.99 mL	19.98 mL
2 mM	1.00 mL	4.99 mL	9.99 mL
10 mM	0.20 mL	1.00 mL	2.00 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Tan Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J.Med.Chem. 2015 PMID: 25075558

Product Documents for TL4-12