Dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50
= 0.50 μ
M for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki
values are 0.25, 8.65, 11.90 and 15.25 μ
M for CK2, PIM1, DYRK1a and HIPK2 respectively).
Soluble to 25 mM in DMSO
Store at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The selectivity of inhibitors of protein kinase CK2: an update.
Pagano et al.