TMCB

Key Product Details

Product Description

TMCB is a dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC₅₀ = 0.50 μM for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (K_i values are 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2 respectively).

Product Specifications for TMCB

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TMCB

The following data is based on the product molecular weight 534.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	7.48 mL	37.40 mL	74.79 mL
1.25 mM	1.50 mL	7.48 mL	14.96 mL
2.5 mM	0.75 mL	3.74 mL	7.48 mL
12.5 mM	0.15 mL	0.75 mL	1.50 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

• Pagano The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 2008 PMID: 18588507

Product Documents for TMCB