TMEM97 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-30437

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Mouse

Cited:

Mouse

Applications

Validated:

Western Blot, ICC/IF (Negative)

Cited:

Western Blot, Block/Neutralize, IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all TMEM97 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide made to an internal portion of the mouse TMEM97 protein (within residues 20-100. [Swiss-Prot# Q8VD00]

Localization

Membrane; Multi-pass membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

24 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TMEM97 Antibody - BSA Free

Western Blot: TMEM97 AntibodyBSA Free [NBP1-30437]

Western Blot: TMEM97 AntibodyBSA Free [NBP1-30437]

Western Blot: TMEM97 Antibody [NBP1-30437] - Analysis of TMEM97 in NIH/3T3 using NBP1-30437.
TMEM97 Antibody - BSA Free

Western Blot: TMEM97 Antibody - BSA Free [NBP1-30437] -

Role of EC on the expression of APP, TMEM97, PGRMC1, and A beta in retina treated with NaIO3. (A–D) Representative Western blot images and quantitative analysis of APP, TMEM97, and PGRMC1 levels. (E) Representative immunofluorescence images show sub-RPE A beta accumulation in the three groups. (F) Quantification of A beta fluorescence intensity in the RPE and sub-RPE layer. A beta (red), DAPI (blue). White arrows indicate sub-RPE A beta deposits. INL, inner nuclear layer; ONL, outer nuclear layer; RPE, retinal pigment epithelium. Values are presented as mean with SEM; n = 3 or 4. *p < 0.05, **p < 0.01, ***p < 0.001. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/35833100), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Applications for TMEM97 Antibody - BSA Free

Application
Recommended Usage

Western Blot

2 ug/ml
Application Notes
This TMEM97 antibody is useful for Western blot where a band is seen ~24 kDa. It is not recommended for ICC/IF.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TMEM97

TMEM97 (transmembrane protein 97 or protein MAC30) is a member of IGFBP/insulin-like growth factor-binding protein family and is implicated in several biological processes wherein it acts through its regulatory effects on IGF activity. It is a multi-pass membrane protein which is localized in nuclear and cell membranes, RER and lysosomes, and is expressed in several normal tissues including brain, lung, heart, skeletal muscles, testis, ovary, and pregnant uterus. TMEM97 was originally identified as overexpressed in meningiomas, however, later it was found to exhibit altered expression in different types of cancers. The absence or downregulation of TMEM97 expression in pancreatic cancer suggests that it may acts as a tumor suppressor in pancreatic cancer. Contrastingly, its expression is stronger in breast, esophageal, stomach, colon, and oral squamous cell cancers than the corresponding normal tissues. Its physiological function is largely unknown, however, it has been suggested to implicate in cellular proliferation/differentiation and regulation of cholesterol homeostasis.

Long Name

Sigma intracellular receptor 2

Alternate Names

MAC30, S2R, Sigma-2 receptor, Sigma2 receptor

Entrez Gene IDs

27346 (Human); 69071 (Mouse)

Gene Symbol

TMEM97

UniProt

Q5BJF2 (Human), Q8VD00 (Mouse)

Additional TMEM97 Products

Product Documents for TMEM97 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for TMEM97 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for TMEM97 Antibody - BSA Free

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