TNP-ATP triethylammonium salt (CAS 61368-63-6): R&D Systems
Catalog Number: 2464
Chemical Name: 2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate tetra(triethylammonium) salt
Biological Activity
High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.
Technical Data
  • M.Wt:
    1123.04
  • Formula:
    C16H13N8O19P3.C24H64N4
  • Solubility:
    Soluble in water (supplied pre-dissolved at a concentration of 10mM)
  • Purity:
    >95%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    61368-63-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors.
    Virginio et al.
    Mol.Pharmacol., 1998;53:969
  2. 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels.
    Lewis et al.
    Br.J.Pharmacol., 1998;124:1463
  3. Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP).
    Burgard et al.
    Mol.Pharmacol., 2000;58:1502
  4. Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors.
    Spelta et al.
    Br.J.Pharmacol., 2002;135:1524
  5. The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels.
    Thomas et al.
    J.Physiol., 1998;509.2:411
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TNP-ATP triethylammonium salt include:

3 Citations: Showing 1 - 3
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  1. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells.
    Authors: Ghalali Et al.
    J Biol Chem 2014;289:11601
  2. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    Naunyn Schmiedebergs Arch Pharmacol 2013;305:F396
  3. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
    Authors: Manohar Et al.
    J Leukoc Biol 2012;92:787

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