TNP-ATP triethylammonium salt

Name: TNP-ATP triethylammonium salt
Brand: Tocris Bioscience
SKU: 2464
Price: 408 USD
Availability: InStock

Tocris Bioscience | Catalog # 2464

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Citations (17)

Product Documents

Potent and selective P2X antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective P2X antagonist

View all P2X Receptor Antagonists »

Product Description

TNP-ATP triethylammonium salt is a high affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X₁, P2X₃ and heteromeric P2X_2/3 receptors with IC₅₀ values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X₂, P2X₄ and P2X₇.

Product Specifications for TNP-ATP triethylammonium salt

Molecular Weight

1123.04

Formula

C₁₆H₁₃N₈O₁₉P₃.4C₆H₁₆N

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate tetra(triethylammonium) salt

PubChem ID

75358143

InChI Key

XTSNRUFLZVGKOU-NRBYJGOSSA-O

SMILES

NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP([O-])(O)=O)([O-])=O)([O-])=O)[C@]4([H])[C@]([H])3OC(C([N+]([O-])=O)=C/C(C=C5[N+]([O-])=O)=[N+]([O-])/[O-])5O4)C=N2)=NC=N1.CC[N+](CC)([H])CC.CC[N+](CC)([H])CC.CC[N+](CC)([H])CC.CC[N+](CC)([H])CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Calculators

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Mass

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

Spelta Kinetics of antagonist actions at rat P2X_2/3 heteromeric receptors. Br.J.Pharmacol. 2002 PMID: 11906966
Burgard Competitive antagonism of recombinant P2X_(2/3)receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP). Mol.Pharmacol. 2000 PMID: 11093790
Lewis 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 1998 PMID: 9723959
Thomas The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 1998 PMID: 9575290
Virginio Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X₁, P2X₃ and heteromeric P2X_2/3 receptors. Mol.Pharmacol. 1998 PMID: 9614197

Product Documents for TNP-ATP triethylammonium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for TNP-ATP triethylammonium salt

For research use only

Citations for TNP-ATP triethylammonium salt

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