TNP-ATP triethylammonium salt
Chemical Name: 2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate tetra(triethylammonium) salt
Biological ActivityHigh affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors.
Spelta et al.
Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP).
Burgard et al.
Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors.
Virginio et al.
2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels.
Lewis et al.
The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels.
Thomas et al.
Citations for TNP-ATP triethylammonium salt
The citations listed below are publications that use Tocris products. Selected citations for TNP-ATP triethylammonium salt include:
4 Citations: Showing 1 - 4
Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons.
Authors: Mohammed Et al.
Sci Rep 2017;7:45221
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells.
Authors: Ghalali Et al.
J Biol Chem 2014;289:11601
Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
Authors: Shabir Et al.
Naunyn Schmiedebergs Arch Pharmacol 2013;305:F396
ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
Authors: Manohar Et al.
J Leukoc Biol 2012;92:787
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