High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1
and heteromeric P2X2/3
receptors with IC50
values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors.
Virginio et al.
2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels.
Lewis et al.
The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels.
Thomas et al.
The citations listed below are publications that use Tocris products. Selected citations for TNP-ATP triethylammonium salt include:
Showing Results 1 - 3 of 3