Chemical Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Biological ActivityTolcapone is a COMT inhibitor. Inhibits both brain and peripheral COMT. Also binds transthyretin (TTR) with high affinity (Kd1 and Kd2 values are 21 and 58 nM, respectively). Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat.
Männistö et al.
Repositioning tolc. as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.
Sant'Anna et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Tolcapone
There are currently no reviews for this product. Be the first to review Tolcapone and earn rewards!
Have you used Tolcapone?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image