Catalog Number: 5864
Alternate Names: Tasmar, Ro 40-7592
Chemical Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Biological Activity
COMT inhibitor. Inhibits both brain and peripheral COMT. Also binds transthyretin (TTR) with high affinity (Kd1 and Kd2 values are 21 and 58 nM, respectively). Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Orally bioavailable.
Technical Data
  • M.Wt:
    273.24
  • Formula:
    C14H11NO5
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    134308-13-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.
    Sant'Anna et al.
    Nat.Commun., 2016;7:10787
  2. Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat.
    Männistö et al.
    Br.J.Pharmacol., 1992;105:569

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