Chemical Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Biological Activity COMT inhibitor. Inhibits both brain and peripheral COMT. Also binds transthyretin (TTR) with high affinity (Kd1 and Kd2 values are 21 and 58 nM, respectively). Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Orally bioavailable.
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Store at +4°C
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