Tolcapone

Catalog # Availability Size / Price Qty
5864/10
5864/50
Cat.No. 5864 - Tolcapone | C14H11NO5 | CAS No. 134308-13-7
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Description: COMT inhibitor; also inhibits transthyretin aggregation
Alternative Names: Tasmar, Ro 40-7592

Chemical Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone

Purity: ≥99%

Product Details
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Biological Activity

COMT inhibitor. Inhibits both brain and peripheral COMT. Also binds transthyretin (TTR) with high affinity (Kd1 and Kd2 values are 21 and 58 nM, respectively). Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Orally bioavailable.

Technical Data

M.Wt:
273.24
Formula:
C14H11NO5
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
134308-13-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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