Catalog Number: 0187
Chemical Name: (±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid
Biological Activity
Equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD. Selective agonist for metabotropic glutamate receptors; active at both group I and group II mGlu receptors (EC50 values are 2, 15, 23 and ~800 μM at mGluR2, mGluR1, mGluR5 and mGluR4 respectively). (1S,3R)-ACPD (Cat. No. 0284) and cis-ACPD (Cat. No. 0186) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in water with gentle warming and to 50 mM in 1eq. NaOH
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Molecular diversity of glutamate receptors and implications for brain functions.
    Science, 1992;258:597
  2. Metabotropic glutamate receptors: novel targets for drug development.
    Knopfel et al.
    J.Med.Chem., 1995;38:1417
  3. The metabotropic glutamate receptors: structure and functions.
    Pin and Duvoisin
    Neuropharmacology, 1995;34:1
  4. Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentance analogues of glutamic acid
    Conti et al.
    Farmaco, 2002;57:889
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