Chemical Name: (±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid
Biological Activity(±)-trans-ACPD is an equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD. Selective agonist for metabotropic glutamate receptors; active at both group I and group II mGlu receptors (EC50 values are 2, 15, 23 and ~800 μM at mGluR2, mGluR1, mGluR5 and mGluR4 respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentance analogues of glutamic acid
Conti et al.
Molecular diversity of glutamate receptors and implications for brain functions.
Metabotropic glutamate receptors: novel targets for drug development.
Knopfel et al.
The metabotropic glutamate receptors: structure and functions.
Pin and Duvoisin
Citations for (±)-trans-ACPD
The citations listed below are publications that use Tocris products. Selected citations for (±)-trans-ACPD include:
7 Citations: Showing 1 - 7
Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
Authors: Rojas Et al.
Mol Pharmacol 2013;83:106
Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling.
Authors: Coulon Et al.
Front Cell Neurosci 2011;4:132
Long-term modifications in the strength of excitatory associative inputs in the piriform cortex.
Authors: Young and Sun
Chem Senses 2007;32:783
Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
J Neurosci 2005;25:5502
PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
Authors: Ying and Goldstein
Mol Pain 2005;1:2
Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus.
Authors: Fujino and Oertel
Proc Natl Acad Sci U S A 2003;100:265
Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
Authors: Nishi Et al.
Proc Natl Acad Sci U S A 2003;100:1322
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