Tranylcypromine hydrochloride

Tocris Bioscience | Catalog # 3852

Irreversible inhibitor of LSD1; also inhibits MAO
Tocris Bioscience

Key Product Details

Description

Irreversible inhibitor of LSD1; also inhibits MAO

Alternative Names

2-PCPA
View all Monoamine Oxidase (MAO) Inhibitors »

Product Description

Tranylcypromine hydrochloride is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021 (Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.

For more information about how Tranylcypromine hydrochloride may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

Product Specifications for Tranylcypromine hydrochloride

Molecular Weight

169.65

Formula

C9H11N.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(±)-trans-2-Phenylcyclopropylamine hydrochloride

CAS Number

1986-47-6

PubChem ID

2723716

InChI Key

ZPEFMSTTZXJOTM-OULXEKPRSA-N

SMILES

N[C@H]1[C@H]([C@]2=CC=CC=C2)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.96 100
DMSO 16.96 100

Preparing Stock Solutions for Tranylcypromine hydrochloride

The following data is based on the product molecular weight 169.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.89 mL 29.47 mL 58.94 mL
5 mM 1.18 mL 5.89 mL 11.79 mL
10 mM 0.59 mL 2.95 mL 5.89 mL
50 mM 0.12 mL 0.59 mL 1.18 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

Product Documents for Tranylcypromine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Tranylcypromine hydrochloride

For research use only

Related Research Areas

Oxidases and Oxygenases
Redox Enzymes

Citations for Tranylcypromine hydrochloride

Customer Reviews for Tranylcypromine hydrochloride (2)

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  • We got expected effect on cells
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Neural Stem Cells
    Verified Customer | Posted 06/25/2020
    Cells are treated with 2 µM Tranylcypromine hydrochloride.
    Tranylcypromine hydrochloride 3852
  • To start reprogramming, cultures were switched to reprogramming medium (ES medium supplemented with 10 mM Parnate)
    Name: Peng Liu
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: ips
    Verified Customer | Posted 12/04/2019
    To start reprogramming, cultures were switched to reprogramming medium (ES medium supplemented with 10 mM Parnate, 3 mM Chir99021, 1 mM A83-01, and 10 mM Forskolin)
    Tranylcypromine hydrochloride 3852

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