Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021
(Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.
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All Tocris products are intended for laboratory research use only.
Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.
Li et al.
Stem Cells, 2009;27:2992
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.
Lee et al.
trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.
Schmidt and McCafferty
The citations listed below are publications that use Tocris products. Selected citations for Tranylcypromine hydrochloride include:
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