Catalog Number: 3852
Alternate Names: 2-PCPA
Chemical Name: (±)-trans-2-Phenylcyclopropylamine hydrochloride
Biological Activity
Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021 (Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.
Technical Data
  • M.Wt:
    169.65
  • Formula:
    C9H11N.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    1986-47-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.
    Li et al.
    Stem Cells, 2009;27:2992
  2. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.
    Lee et al.
    Chem.Biol., 2006;13:563
  3. trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.
    Schmidt and McCafferty
    Biochemistry, 2007;46:4408
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tranylcypromine hydrochloride include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
    Authors: Zhang Et al.
    Cell Stem Cell 2016;18:653
  2. Functional annotation of native enhancers with a Cas9-histone demethylase fusion.
    Authors: Kearns Et al.
    Nat Methods 2015;12:401
  3. Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules.
    Authors: Li Et al.
    Cell 2011;21:196

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