Tranylcypromine hydrochloride

  ( 4 citations )    
Product Datasheet
Catalog Number:3852
Alternate Names:2-PCPA
Chemical Name:(±)-trans-2-Phenylcyclopropylamine hydrochloride
Product Details
Citations (4)
Reviews
Biological Activity
Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021 (Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.
Technical Data
  • M.Wt:
    169.65
  • Formula:
    C9H11N.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    1986-47-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tranylcypromine hydrochloride include:

4 Citations: Showing 1 - 4
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  1. CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency.
    Authors: Liu Et al.
    Cell Stem Cell  2018;22:252
  2. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
    Authors: Zhang Et al.
    Cell Stem Cell  2016;18:653
  3. Functional annotation of native enhancers with a Cas9-histone demethylase fusion.
    Authors: Kearns Et al.
    Nat Methods  2015;12:401
  4. Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules.
    Authors: Li Et al.
    Cell  2011;21:196

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