Chemical Name: (±)-trans-2-Phenylcyclopropylamine hydrochloride
Biological ActivityIrreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021 (Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.
Li et al.
Stem Cells, 2009;27:2992
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.
Lee et al.
trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.
Schmidt and McCafferty
Citations for Tranylcypromine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Tranylcypromine hydrochloride include:
8 Citations: Showing 1 - 8
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
Authors: Sheng Et al.
Nat Commun 2018;9:4047
Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs.
Authors: Ping Et al.
Cell Death Dis 2018;9:187
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.
Authors: Li Et al.
Nat Commun 2018;9:1420
Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts.
CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency.
Authors: Liu Et al.
Cell Stem Cell 2018;22:252
Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
Authors: Zhang Et al.
Cell Stem Cell 2016;18:653
Functional annotation of native enhancers with a Cas9-histone demethylase fusion.
Authors: Kearns Et al.
Nat Methods 2015;12:401
Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules.
Authors: Li Et al.
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Cells are treated with 2 µM Tranylcypromine hydrochloride.
To start reprogramming, cultures were switched to reprogramming medium (ES medium supplemented with 10 mM Parnate, 3 mM Chir99021, 1 mM A83-01, and 10 mM Forskolin)