Treprostinil
Chemical Name: 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid
Purity: ≥98%
Biological Activity
Treprostinil is a potent prostacyclin (PGI2) analog (EC50 values are 0.6, 1.9 and 6.2 nM at DP1, IP and EP2 receptors respectively). Causes vasodilation of human pulmonary arteries and inhibits NFκB nuclear translocation in human alveolar macrophages in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes.
Fontana et al.
Br.J.Pharmacol., 2007;151:779 -
Binding and activity of the prostacyclin receptor (IP) agonists, trepros. and iloprost, at human prostanoid receptors: trepros. is a potent DP1 and EP2 agonist.
Whittle et al.
Biochem.Pharmacol., 2012;84:68 -
The prostacyclin analogue trepros. blocks NFκB nuclear translocation in human alveolar macrophages.
Raychaudhuri et al.
J.Biol.Chem., 2002;277:33344
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