Catalog Number: 5349
Chemical Name: 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid
Biological Activity
Potent prostacyclin (PGI2) analog (EC50 values are 0.6, 1.9 and 6.2 nM at DP1, IP and EP2 receptors respectively). Causes vasodilation of human pulmonary arteries and inhibits NFκB nuclear translocation in human alveolar macrophages in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist.
    Whittle et al.
    Biochem.Pharmacol., 2012;84:68
  2. The prostacyclin analogue treprostinil blocks NFκB nuclear translocation in human alveolar macrophages.
    Raychaudhuri et al.
    J.Biol.Chem., 2002;277:33344
  3. Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes.
    Fontana et al.
    Br.J.Pharmacol., 2007;151:779
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