hh (+)-Tubocurarine chloride (CAS 57-94-3): R&D Systems
Catalog Number: 2820
Chemical Name: 2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride
Biological Activity
Competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.
Technical Data
  • M.Wt:
    681.65
  • Formula:
    C37H41ClN2O6.HCl
  • Solubility:
    Soluble to 25 mM in water and to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    57-94-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor.
    Pederson and Cohen
    Proc.Natl.Acad.Sci.USA, 1990;87:2785
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (+)-Tubocurarine chloride include:

5 Citations: Showing 1 - 5
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  1. Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine.
    Authors: Pinnock Et al.
    BMC Syst Biol 2015;9:30
  2. Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss.
    Authors: Zachary and Fuchs
    J Neurosci 2015;35:9701
  3. Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors.
    Authors: Freeman Et al.
    Front Behav Neurosci 2013;110:103
  4. Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
    Authors: Saliba Et al.
    J Biol Chem 2012;31:2937
  5. Allosteric block of KCa2 channels by apamin.
    Authors: Lamy Et al.
    J Neurophysiol 2010;285:27067

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