Chemical Name: 2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride
Biological Activity(+)-Tubocurarine chloride is a competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor.
Pederson and Cohen
Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine.
Peters et al.
The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons.
Wotring and Yoon
Citations for (+)-Tubocurarine chloride
The citations listed below are publications that use Tocris products. Selected citations for (+)-Tubocurarine chloride include:
10 Citations: Showing 1 - 10
Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.
Authors: Corns Et al.
Nat Commun 2018;9:4015
Ex vivo Whole-cell Recordings in Adult Drosophila Brain.
Authors: Roemmich Et al.
Bio Protoc 2018;8
Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
Authors: Zhu Et al.
Nat Commun 2017;8:1676
A cellular mechanism for inverse effectiveness in multisensory integration.
Authors: Truszkowski Et al.
Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine.
Authors: Pinnock Et al.
BMC Syst Biol 2015;9:30
Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss.
Authors: Zachary and Fuchs
J Neurosci 2015;35:9701
Synaptic and circuit mechanisms promoting broadband transmission of olfactory stimulus dynamics.
Authors: Nagel Et al.
Nat Neurosci 2015;18:56
Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors.
Authors: Freeman Et al.
Front Behav Neurosci 2013;110:103
Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
Authors: Saliba Et al.
J Biol Chem 2012;31:2937
Allosteric block of KCa2 channels by apamin.
Authors: Lamy Et al.
J Neurophysiol 2010;285:27067
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