(+)-Tubocurarine chloride

Catalog # Availability Size / Price Qty
(+)-Tubocurarine chloride | CAS No. 57-94-3 | Additional Nicotinic Receptor Antagonists
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Description: nAChR antagonist

Chemical Name: 2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride

Purity: ≥98%

Product Details
Citations (10)

Biological Activity

(+)-Tubocurarine chloride is a competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.

Technical Data

Soluble to 25 mM in water
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor.
    Pederson and Cohen
    Proc.Natl.Acad.Sci.USA, 1990;87:2785
  2. Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine.
    Peters et al.
    Neurosci.Letts., 1990;110:107
  3. The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons.
    Wotring and Yoon
    Neurosci., 1995;67:293

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Citations for (+)-Tubocurarine chloride

The citations listed below are publications that use Tocris products. Selected citations for (+)-Tubocurarine chloride include:

10 Citations: Showing 1 - 10


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