-opioid agonist. At higher concentrations blocks Na+
channels. Separate isomers (+)-U-50488
also available (Cat. Nos. 0471 and 0496 respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
U-50,488 blocks the development of morphine tolerance and dependence at a very low dose in guinea pigs.
Pao-Luh Tao et al.
Activation of kappa opioid receptors by U-50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices.
Suarez-Roca and Maixner
Cardiovascular actions of the κ-agonist, U-50-488H, in the absence and presence of opioid receptor blockade.
Pugsley et al.
Blockade of the development of morphine tolerance by U-50,488, an AVP antagonist or MK 801 in the rat hippocampal slice.
Su et al.
The citations listed below are publications that use Tocris products. Selected citations for (±)-U-50488 hydrochloride include:
Showing Results 1 - 3 of 3