Catalog Number: 0495
Chemical Name: trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Biological Activity
Selective κ-opioid agonist. At higher concentrations blocks Na+ channels. Separate isomers (+)-U-50488 and (-)-U-50488 also available (Cat. Nos. 0471 and 0496 respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. U-50,488 blocks the development of morphine tolerance and dependence at a very low dose in guinea pigs.
    Pao-Luh Tao et al.
    Eur.J.Pharmacol., 1994;256:281
  2. Activation of kappa opioid receptors by U-50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices.
    Suarez-Roca and Maixner
    J.Pharmacol.Exp.Ther., 1993;264:648
  3. Cardiovascular actions of the κ-agonist, U-50-488H, in the absence and presence of opioid receptor blockade.
    Pugsley et al.
    Br.J.Pharmacol., 1992;105:521
  4. Blockade of the development of morphine tolerance by U-50,488, an AVP antagonist or MK 801 in the rat hippocampal slice.
    Su et al.
    Br.J.Pharmacol., 1998;123:625

The citations listed below are publications that use Tocris products. Selected citations for (±)-U-50488 hydrochloride include:

Showing Results 1 - 3 of 3

  1. Development of functionally selective, small molecule agonists at kappa opioid receptors.
    Authors: Zhou Et al.
    J Biol Chem
  2. Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
    Authors: Kharmate Et al.
    Cancer Cell Int
  3. GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
    Authors: Grachev Et al.
Tocris Small Molecules
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(-)-U-50488 hydrochloride

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