(±)-U-50488 hydrochloride

  ( 5 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0495
Chemical Name:trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity
Selective κ-opioid agonist. At higher concentrations blocks Na+ channels.

(-)-enantiomer and (+)-enantiomer also available.

Technical Data
  • M.Wt:
    405.79
  • Formula:
    C19H26Cl2N2O.HCl
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    67197-96-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (±)-U-50488 hydrochloride include:

5 Citations: Showing 1 - 5
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  1. Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress
    Authors: Polter
    Elife  2017;6:e23785
  2. Development of functionally selective, small molecule agonists at kappa opioid receptors.
    Authors: Zhou Et al.
    J Biol Chem  2013;288:36703
  3. Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
    Authors: Kharmate Et al.
    Cancer Cell Int  2013;13:93
  4. GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
    Authors: Grachev Et al.
    Pain  2012;7:e44344
  5. Medial dorsal hypothalamus mediates the inhibition of reward seeking after extinction.
    Authors: Marchant Et al.
    J Neurosci  2010;30:14102

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Average Rating: 5 (Based on 1 review)

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  Rat Matthew Banks 01/05/2018
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Summary

Species Rat

Other Experimental Details

Other Experimental Details soluble in water up to 5.6 mg/mL

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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