Chemical Name: trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Biological Activity(-)-U-50488 hydrochloride is a more active enantiomer of (±)-U-50488.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist.
De Costa et al.
FEBS Lett., 1987;223:335
Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors.
Morrone et al.
Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central DA (D2) receptors of the rat.
Reddy and Bhargava
Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells.
Zhu et al.
Citation for (-)-U-50488 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for (-)-U-50488 hydrochloride include:
1 Citation: Showing 1 - 1
Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis
Authors: Pirino Et al.
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We have used this product numerous times in animal behavior studies and with consistent results.