Catalog Number: 0496
Chemical Name: trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Biological Activity

More active enantiomer of (±)-U-50488.

Racemate and (+)-enantiomer also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist.
    De Costa et al.
    FEBS Lett., 1987;223:335
  2. Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central dopamine (D2) receptors of the rat.
    Reddy and Bhargava
    Eur.J.Pharmacol., 1993;235:23
  3. Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors.
    Morrone et al.
    Br.J.Pharmacol., 1993;109:48
  4. Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells.
    Zhu et al.
    J.Pharmacol.Exp.Ther., 1998;285:28
Tocris Small Molecules
Description Application Cat# Citations Images  

(±)-U-50488 hydrochloride

0495 4  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
Average Rating: 5 (Based on 1 review)

Have you used (-)-U-50488 hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Read what people are saying who have used (-)-U-50488 hydrochloride.

Filter by Ratings
All Ratings
Filter by Applications
All Applications
Filter by Species
All Species

Images Ratings Applications Species Reviewed By Date Details
  Anonymous 10/30/2017

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information


Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 


Customer Information