Catalog Number: 0496
Chemical Name: trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Biological Activity
More active enantiomer of (±)-U-50488 (Cat. No. 0495). (+)-U-50488 hydrochloride (Cat. No. 0471) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist.
    De Costa et al.
    FEBS Lett., 1987;223:335
  2. Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central dopamine (D2) receptors of the rat.
    Reddy and Bhargava
    Eur.J.Pharmacol., 1993;235:23
  3. Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors.
    Morrone et al.
    Br.J.Pharmacol., 1993;109:48
  4. Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells.
    Zhu et al.
    J.Pharmacol.Exp.Ther., 1998;285:28
Tocris Small Molecules
Description Application Cat# Citations Images  

(±)-U-50488 hydrochloride

0495 3  
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