UBP 302

  ( 3 citations )    
Product Datasheet
Catalog Number:2079
Chemical Name:(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione
Product Details
Citations (3)
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Biological Activity
Potent and selective GLUK5 (GluR5)-subunit containing kainate receptor antagonist (apparent KD = 402 nM); active enantiomer of UBP 296 (Cat. No. 2078). Displays ~ 260-fold selectivity over AMPA receptors, ~ 90-fold selectivity over recombinant human GLUK6- and GLUK2-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Also protects against soman-induced seizures and neuronal degeneration for up to 30 days when administered one hour after soman exposure.

Technical Data
  • M.Wt:
    333.3
  • Formula:
    C15H15N3O6
  • Solubility:
    Soluble to 25 mM in 1eq. NaOH and to 20 mM in DMSO with gentle warming
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    745055-91-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for UBP 302 include:

3 Citations: Showing 1 - 3
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  1. PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.
    Authors: Caiati Et al.
    J Neurosci  2013;33:2973
  2. Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro.
    Authors: Randall Et al.
    Eur J Neurosci  2011;33:914
  3. Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG.
    Authors: Talpalar and Kiehn
    Front Neural Circuits  2010;4

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