Chemical Name: (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione
Biological ActivityUBP 302 is a potent and selective GluK1 (formally GluR5)-subunit containing kainate receptor antagonist (apparent KD = 402 nM); active enantiomer of UBP 296 (Cat. No. 2078). Displays ~ 260-fold selectivity over AMPA receptors, ~ 90-fold selectivity over recombinant human GluK2 (formally GluR6) and GluK5 (formally KA2)-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Also protects against soman-induced seizures and neuronal degeneration for up to 30 days when administered one hour after soman exposure.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
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The Limitations of D.pam as a Treatment for Nerve Agent-Induced Seizures and Neuropathology in Rats: Comparison with UBP302.
Apland et al.
Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist.
More et al.
Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.
Dolman et al.
Citations for UBP 302
The citations listed below are publications that use Tocris products. Selected citations for UBP 302 include:
3 Citations: Showing 1 - 3
PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.
Authors: Caiati Et al.
J Neurosci 2013;33:2973
Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro.
Authors: Randall Et al.
Eur J Neurosci 2011;33:914
Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG.
Authors: Talpalar and Kiehn
Front Neural Circuits 2010;4
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