UBP 302

Catalog # Availability Size / Price Qty
2079/10
2079/50
UBP 302 | CAS No. 745055-91-8 | Kainate Receptor Antagonists
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Description: Potent and selective kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)

Chemical Name: (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

Potent and selective GluK1 (formally GluR5)-subunit containing kainate receptor antagonist (apparent KD = 402 nM); active enantiomer of UBP 296 (Cat. No. 2078). Displays ~ 260-fold selectivity over AMPA receptors, ~ 90-fold selectivity over recombinant human GluK2 (formally GluR6) and GluK5 (formally KA2)-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Also protects against soman-induced seizures and neuronal degeneration for up to 30 days when administered one hour after soman exposure.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
333.3
Formula:
C15H15N3O6
Solubility:
Soluble to 25 mM in 1eq. NaOH and to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at RT
CAS No:
745055-91-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for UBP 302

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