UBP 296

Catalog # Availability Size / Price Qty
2078/10
2078/50
UBP 296 | CAS No. 745055-86-1 | Kainate Receptor Antagonists
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Description: Potent and selective kainate antagonist; selective for GluK1-containing receptors

Chemical Name: (RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

Selective GluK1 (formally GluR5) subunit containing kainate receptor antagonist (apparent KD = 1.09 μM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant hGluK2 (formally hGluR6) and GluK5 (formally KA2) containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers.

Active Enantiomer also available.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
333.3
Formula:
C15H15N3O6
Solubility:
Soluble to 10 mM in 1eq. NaOH with gentle warming and to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
745055-86-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for UBP 296

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