Chemical Name: (RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione
Biological ActivityUBP 296 is a selective GluK1 (formally GluR5) subunit containing kainate receptor antagonist (apparent KD = 1.09 μM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant hGluK2 (formally hGluR6) and GluK5 (formally KA2) containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers.
Active Enantiomer also available.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist.
More et al.
Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.
Dolman et al.
Citation for UBP 296
The citations listed below are publications that use Tocris products. Selected citations for UBP 296 include:
1 Citation: Showing 1 - 1
Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices.
Authors: Albiñana Et al.
Neural Plast 2015;2015:463854
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