Catalog Number: 2078
Chemical Name: (RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione
Biological Activity
Selective GluR5-subunit containing kainate receptor antagonist (apparent KD = 1.09 μM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers.

Active Enantiomer also available.

Technical Data
  • M.Wt:
    333.3
  • Formula:
    C15H15N3O6
  • Solubility:
    Soluble to 10 mM in 1eq. NaOH with gentle warming and to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    745055-86-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.
    Dolman et al.
    J.Med.Chem., 2005;48:7867
  2. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist.
    More et al.
    Neuropharmacology, 2004;47:46
Citations:

The citations listed below are publications that use Tocris products. Selected citations for UBP 296 include:

1 Citations: Showing 1 - 1

  1. Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices.
    Authors: Albiñana Et al.
    Neural Plast 2015;2015:463854
Tocris Small Molecules
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UBP 302

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