Selective GluR5-subunit containing kainate receptor antagonist (apparent KD
= 1.09 μ
M). Displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Active enantiomer UBP 302
(Cat. No. 2079) available.
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All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.
Dolman et al.
Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist.
More et al.
The citations listed below are publications that use Tocris products. Selected citations for UBP 296 include:
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