Selective non-substrate inhibitor of EAAT1 (IC50
values are 660, >300000 and >300000 nM for EAAT1, EAAT2 and EAAT3 respectively). Also demonstrates no significant inhibition at EAAT4 or EAAT5 in a patch-clamp electrophysiology assay (at final concentration up to 10 μ
Soluble to 25 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1.
Jensen et al.
Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101).
Erichsen et al.
Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain.
Abrahamsen et al.
Excitatory amino acid transporters as potential drug targets.
Bunch et al.
The citations listed below are publications that use Tocris products. Selected citations for UCPH 101 include:
Showing Results 1 - 3 of 3