uPSEM 792 hydrochloride

Key Product Details

Product Description

uPSEM 792 hydrochloride is an ultrapotent PSEM (uPSEM) agonist for PSAM⁴-GlyR and PSAM⁴-5HT3 (K_i = 0.7 nM for PSAM⁴-GlyR and <10 nM for PSAM⁴-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM⁴-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (~10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM⁴-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetrant.

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

Product Specifications for uPSEM 792 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for uPSEM 792 hydrochloride

The following data is based on the product molecular weight 277.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.60 mL	18.00 mL	36.00 mL
5 mM	0.72 mL	3.60 mL	7.20 mL
10 mM	0.36 mL	1.80 mL	3.60 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Magnus Ultrapotent chemogenetics for research and potential clinical applications. Science 2019 PMID: 30872534

Product Documents for uPSEM 792 hydrochloride