Varenicline tartrate

Catalog # Availability Size / Price Qty
3754/10
3754/50
Nicotinic (a4b2) Receptor Agonists Small Molecule
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Description: Selective α4β2 nAChR partial agonist; orally active

Chemical Name: 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate

Purity: ≥99%

Product Details
Citations (7)
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Reviews

Biological Activity

Orally active, subtype-selective partial agonist at α4β2 nicotinic receptors (Ki values are 0.06, 240, 322 and 3540 nM for α4β2, α3β4, α7, α1βγδ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo. Also potently activates PSAM4-5-HT3 and PSAM4-GlyR chimeric ion channels (EC50 values are 4 and 1.6 nM, respectively)

Technical Data

M.Wt:
361.37
Formula:
C13H13N3.C4H6O6
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
375815-87-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for Varenicline tartrate

The citations listed below are publications that use Tocris products. Selected citations for Varenicline tartrate include:

7 Citations: Showing 1 - 7

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