Chemical Name: 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h]benzazepine tartrate
Biological ActivityVarenicline tartrate is an orally active, subtype-selective partial agonist at α4β2 nicotinic receptors (Ki values are 0.06, 240, 322 and 3540 nM for α4β2, α3β4, α7, α1βγδ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo. Also potently activates PSAM4-5-HT3 and PSAM4-GlyR chimeric ion channels (EC50 values are 4 and 1.6 nM, respectively)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Varenicline: an α4β2 nicotinic receptor partial agonist for smoking cessation.
Coe et al.
Pharmacological profile of the α4β2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid.
Rollema et al.
Preclinical pharmacology of the α4β2 nAChR partial agonist vareni. related to effects on reward, mood and cognition.
Rollema et al.
Citations for Varenicline tartrate
The citations listed below are publications that use Tocris products. Selected citations for Varenicline tartrate include:
7 Citations: Showing 1 - 7
Direct Effects of Nicotine Exposure on Murine Calvaria and Calvarial Cells.
Authors: Durham Et al.
Sci Rep 2019;9:3805
Ultrapotent chemogenetics for research and potential clinical applications
Authors: Magnus Et al.
Differential effects of α4β2 nicotinic receptor antagonists and partial-agonists on contextual fear extinction in male C57BL/6 mice.
Authors: Kutlu Et al.
Psychopharmacology (Berl) 2018;235:1211
VRC Reduces Context-Induced Relapse to Alcohol-Seeking through Actions in the Nucleus Accumbens.
Authors: Lacroix Et al.
Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP.
Authors: Price Et al.
PLoS One 2015;6:1151
AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology.
Authors: Cippitelli Et al.
Br J Pharmacol 2015;172:1834
Chemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRs.
Authors: Kuryatov Et al.
Sci Rep 2013;8:e62246
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for Varenicline tartrate
There are currently no reviews for this product. Be the first to review Varenicline tartrate and earn rewards!
Have you used Varenicline tartrate?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image