Chemical Name: (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
Biological ActivityYAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties.
Song et al.
Cancer Res., 2014;74:4170
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.
Liu-Chittenden et al.
Genes Dev., 2012;26:1300
The clinically used photosensitizer vertep. (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation.
Brodowska et al.
Exp.Eye Res., 2014;124:67
Citations for Verteporfin
The citations listed below are publications that use Tocris products. Selected citations for Verteporfin include:
7 Citations: Showing 1 - 7
Generation of blastocyst-like structures from mouse embryonic and adult cell cultures.
Authors: Li Et al.
Pulmonary pericytes regulate lung morphogenesis.
Authors: Kato Et al.
Nat Commun 2018;9:2448
Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species.
Sci Rep 2018;8(1):14358
Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size.
Authors: Yosefzon Et al.
Mol Cell 2018;70:573
Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.
Authors: An Et al.
Cell Rep 2018;25:702
Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells.
Authors: Fisher Et al.
A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.
Authors: Seong Et al.
Cancer Res 2017;77:696
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Reviews for Verteporfin
Average Rating: 5 (Based on 2 Reviews)
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Used it in in vitro treatment assays at concentration of 1 to 10microM for 72 hours. The treatment resulted in a significant time- and dose-dependent inhibition of cell growth & viability.