Chemical Name: (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
Biological ActivityVerteporfin is a YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties.
Song et al.
Cancer Res., 2014;74:4170
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.
Liu-Chittenden et al.
Genes Dev., 2012;26:1300
The clinically used photosensitizer vertep. (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation.
Brodowska et al.
Exp.Eye Res., 2014;124:67
Citations for Verteporfin
The citations listed below are publications that use Tocris products. Selected citations for Verteporfin include:
7 Citations: Showing 1 - 7
Generation of blastocyst-like structures from mouse embryonic and adult cell cultures.
Authors: Li Et al.
Pulmonary pericytes regulate lung morphogenesis.
Authors: Kato Et al.
Nat Commun 2018;9:2448
Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species.
Sci Rep 2018;8(1):14358
Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size.
Authors: Yosefzon Et al.
Mol Cell 2018;70:573
Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.
Authors: An Et al.
Cell Rep 2018;25:702
Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells.
Authors: Fisher Et al.
A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.
Authors: Seong Et al.
Cancer Res 2017;77:696
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