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Verteporfin

Catalog #: 5305
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5305/10
Verteporfin | CAS No. 129497-78-5 | Additional Transcription Factor Compounds
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Description: YAP inhibitor
Alternative Names: Visudyne

Chemical Name: (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

Purity: ≥95%

Product Details
Citations (7)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Verteporfin is a YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.

Technical Data

M.Wt:
718.79
Formula:
C41H42N4O8
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
129497-78-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Verteporfin

The citations listed below are publications that use Tocris products. Selected citations for Verteporfin include:

7 Citations: Showing 1 - 7

  1. Generation of blastocyst-like structures from mouse embryonic and adult cell cultures.
    Authors: Li Et al.
    Cell  2019;179:687
  2. Pulmonary pericytes regulate lung morphogenesis.
    Authors: Kato Et al.
    Nat Commun  2018;9:2448
  3. Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species.
    Authors: Eales
    Sci Rep  2018;8(1):14358
  4. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size.
    Authors: Yosefzon Et al.
    Mol Cell  2018;70:573
  5. Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.
    Authors: An Et al.
    Cell Rep  2018;25:702
  6. Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells.
    Authors: Fisher Et al.
    Oncotarget  2017;8:110257
  7. A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.
    Authors: Seong Et al.
    Cancer Res  2017;77:696

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