Viral Yellow Fever Virus NS1 Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB9776S Datasheet / COA / SDS

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FAB9776S-100UG

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Viral Yellow Fever Virus NS1 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Viral

Specificity

Detects Yellow Fever Virus NS1 in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 994706

Purification

Protein A or G purified

Immunogen

Human embryonic kidney cell HEK293-derived Yellow Fever Virus NS1
Gln780-His1134
Accession # P03314

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Yellow Fever Virus NS1

Yellow fever virus (YFV) non-structural protein 1 (NS1) is produced by yellow fever virus (YFV), a mosquito-borne flavivirus that is responsible for numerous epidemics of yellow fever disease with high fatality rates (1). Flavivirus NS1 is a multifunctional virulence factor. The glycosylated NS1 exists as a membrane‑associated dimer after translocation into the endoplasmic reticulum lumen, where it is essential for viral genome replication (2). The secreted hexamer NS1 is involved in immune evasion and pathogenesis; it is identified as a potential diagnostic marker for early detection of the virus infections (2). Mature viral YFV NS1 contains 352 amino acids (afa) and shares high structural similarity to other flavivirus NS1 proteins, such as DENV and ZIKV.

Entrez Gene IDs

1502173 (Viral)

Alternate Names

Yellow Fever Virus NS1; YFV NS1; YFV_NS1; YFV-NS1