Key Product Details

Species Reactivity

Human

Applications

Western Blot, ICC/IF (Negative)

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 730801

Format

Azide and BSA Free
View all VISTA/B7-H5/PD-1H Primary Antibodies »

Product Specifications

Immunogen

Partial recombinant human VISTA/B7-H5 (amino acids 33-194) [UniProt Q9H7M9]

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for VISTA/B7-H5/PD-1H Antibody (730801) - Azide and BSA Free

Application
Recommended Usage

ICC/IF (Negative)

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: VISTA/B7-H5/PD-1H

Platelet Receptor Gi24, also known as Dies1 (Differentiation of ESC-1), VISTA (V-domain Ig suppressor of T cell activation), SISP1 and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162 aa extracellular region with one V-type Ig-like domain and a 96 aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment. Over aa 33-194, human Gi24 shares 70% and 67% aa identity with mouse and rat Gi24, respectively.

Alternate Names

4632428N05Rik, B7-H5, C10orf54, Dies1, Gi24, PD-1H, PD1H, SISP1, VSIR

Gene Symbol

VSIR

Additional VISTA/B7-H5/PD-1H Products

Product Documents for VISTA/B7-H5/PD-1H Antibody (730801) - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for VISTA/B7-H5/PD-1H Antibody (730801) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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