Chemical Name: N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide
Biological ActivityHighly selective muscarinic M1 antagonist (Ki = 14.87 nM). Targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning.
Sheffler et al.
Citations for VU 0255035
The citations listed below are publications that use Tocris products. Selected citations for VU 0255035 include:
5 Citations: Showing 1 - 5
Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
Authors: Zhu Et al.
Nat Commun 2017;8:1676
Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
Authors: Martin Et al.
Mar Drugs 2015;9:457
M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury.
Authors: Urrunaga Et al.
Proc Natl Acad Sci U S A 2015;78:66
M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice.
Authors: Rachakonda Et al.
Sci Rep 2015;5:14110
Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
Authors: Shin Et al.
Front Cell Neurosci 2015;112:8124
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for VU 0255035
There are currently no reviews for this product. Be the first to review VU 0255035 and earn rewards!
Have you used VU 0255035?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image