VU 0255035

Key Product Details

Product Description

VU 0255035 is a highly selective muscarinic M₁ antagonist (K_i = 14.87 nM). Targets the M₁ orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.

Product Specifications for VU 0255035

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0255035

The following data is based on the product molecular weight 432.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.56 mL	57.80 mL	115.60 mL
1 mM	2.31 mL	11.56 mL	23.12 mL
2 mM	1.16 mL	5.78 mL	11.56 mL
10 mM	0.23 mL	1.16 mL	2.31 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 31 publications citing the usage of this product.

• Sheffler A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol.Pharmacol. 2009 PMID: 19407080

Product Documents for VU 0255035