Highly selective muscarinic M1
= 14.87 nM). Targets the M1
orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.
Soluble to 20 mM in DMSO
Store at -20°C
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A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning.
Sheffler et al.
The citations listed below are publications that use Tocris products. Selected citations for VU 0255035 include:
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