VU 0255035

  ( 4 citations )    
Product Datasheet
Catalog Number:3727
Chemical Name:N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide
Product Details
Citations (4)
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Reviews
Biological Activity
Highly selective muscarinic M1 antagonist (Ki = 14.87 nM). Targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.
Technical Data
  • M.Wt:
    432.52
  • Formula:
    C18H20N6O3S2
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    1135243-19-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for VU 0255035 include:

4 Citations: Showing 1 - 4
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  1. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
    Authors: Martin Et al.
    Mar Drugs  2015;9:457
  2. M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury.
    Authors: Urrunaga Et al.
    Proc Natl Acad Sci U S A  2015;78:66
  3. M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice.
    Authors: Rachakonda Et al.
    Sci Rep  2015;5:14110
  4. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    Front Cell Neurosci  2015;112:8124

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