Chemical Name: N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide
Biological ActivityHighly selective muscarinic M1 antagonist (Ki = 14.87 nM). Targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning.
Sheffler et al.
Citations for VU 0255035
The citations listed below are publications that use Tocris products. Selected citations for VU 0255035 include:
5 Citations: Showing 1 - 5
Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
Authors: Zhu Et al.
Nat Commun 2017;8:1676
Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
Authors: Martin Et al.
Mar Drugs 2015;9:457
M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury.
Authors: Urrunaga Et al.
Proc Natl Acad Sci U S A 2015;78:66
M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice.
Authors: Rachakonda Et al.
Sci Rep 2015;5:14110
Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
Authors: Shin Et al.
Front Cell Neurosci 2015;112:8124
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