Chemical Name: N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide
Biological ActivityHighly selective muscarinic M1 antagonist (Ki = 14.87 nM). Targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning.
Sheffler et al.
Citations for VU 0255035
The citations listed below are publications that use Tocris products. Selected citations for VU 0255035 include:
5 Citations: Showing 1 - 5
Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
Authors: Zhu Et al.
Nat Commun 2017;8:1676
Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
Authors: Martin Et al.
Mar Drugs 2015;9:457
M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury.
Authors: Urrunaga Et al.
Proc Natl Acad Sci U S A 2015;78:66
M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice.
Authors: Rachakonda Et al.
Sci Rep 2015;5:14110
Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
Authors: Shin Et al.
Front Cell Neurosci 2015;112:8124
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