Catalog Number: 3727
Chemical Name: N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide
Biological Activity
Highly selective muscarinic M1 antagonist (Ki = 14.87 nM). Targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.
Technical Data
  • M.Wt:
    432.52
  • Formula:
    C18H20N6O3S2
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    1135243-19-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning.
    Sheffler et al.
    Mol.Pharmacol., 2009;76:356
Citations:

The citations listed below are publications that use Tocris products. Selected citations for VU 0255035 include:

3 Citations: Showing 1 - 3
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  1. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
    Authors: Martin Et al.
    Mar Drugs 2015;9:457
  2. M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury.
    Authors: Urrunaga Et al.
    Proc Natl Acad Sci U S A 2015;78:66
  3. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    Front Cell Neurosci 2015;112:8124

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